early in the development of many animals, before transcription begins, any change in the pattern of protein synthesis is attributed to a change in the translational activity or stability of mrna in the egg and early embryo. as a result, translational control is critical for a variety of developmental decisions, including oocyte maturation and initiation of preimplantation development. in this s...

Rabbits fed low-fat, cholesterol-free diets containing casein as the sole protein source develop endogenous hypercholesterolemia (EH). To test the hypothesis that lipoprotein cholesteryl esters in EH rabbits are acyl coenzyme A:cholesterol acyltransferase (ACAT) derived, we treated EH rabbits with CI-976, a potent and selective ACAT inhibitor. In addition, since cholesterol and bile acid synthe...

BACKGROUND The pyrazolyl ketone motif of RO3201195, which exhibits good oral bioavailability and high selectivity for p38 MAPK over other kinases, is a key pharmacophore that could find application in the treatment of Werner syndrome. RESULTS AND DISCUSSION Microwave irradiation promotes Knoevenagel condensation of a β-ketonitrile and formamidine, to give β-aminovinyl ketones, and their subse...

Objective(s):To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. Materials and Methods:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. To t...

adenosine receptor family especially a1 type is expressed in breast cancer cells in which p53 and caspase genes are wild-type. the aim of this study was to investigate the correlation between a1 receptor and either cell apoptosis or proliferation and also to recognize the relationship between this receptor and p53 and the expression of caspases 3, 8 and 9 in mcf-7 cell line. mcf-7 cells were tr...

Background. BDNF and NT-4/5 have been proposed to be involved in the coordinated adaptations of the neuromuscular system to the elevated level of activity, but an activity-dependent expression of neurotrophins in skeletal muscle is not well established. Objectives. We, therefore, investigated the effect of one session of resistance exercise on mRNA expression of some neurotrophins in Slow and ...

objective: astrocytes are the most abundant glial cell type. they may promote or inhibit cns inflammation depending on which cytokines are secreted. astrocytes also have immune roles. il-19, il-20, and il-24 activate a heterodimer receptor composed of the il-20r1 α-chain and the il-20r2 β-chain. it has long been considered that signaling by these receptor complexes affects immunological reactio...

objective(s):to study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. materials and methods:forty new zealand rabbits were randomly divided into five groups with eight rabbits in each group. for each group, bone defects were generated in the left humerus of four rabbits, and in the right humerus of the other four rabbits. to t...