Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (HLA) class-II alleles or haplotypes. Objectives: The present study was under-taken to determine the frequency of HLA class-II alleles in ...

The Editorial by Lone and Puliyel contains several factual errors. It exhibits a time warp, citing old information but not its new details and a disregard for truth by arguments taken out of context. It contains statements that have been disproved. The idea of pentavalent vaccine has ‘technical’ elements – the epidemiological need to introduce hepatitis B (HB) vaccine and Haemophilus influenzae...

BACKGROUND It is important to differentiate whether isolated anti-HBc is due to false positive results or the prior exposure to hepatitis B virus, because individuals with false-positive anti-HBc can benefit from vaccination and their blood can be safely transfused. To distinguish between these two conditions, we evaluated the serologic response to hepatitis B vaccine. METHODS Ninety subjects w...

BACKGROUND/AIMS Patients undergoing maintenance dialysis have an unsatisfactory response to vaccination, including to hepatitis B vaccine. A recombinant HB vaccine containing a new adjuvant system AS04 (HBV-AS04) has been recently developed; a few data exist on the immunogenicity and safety of HBV-AS04 among patients undergoing regular dialysis. All hepatitis B virus-seronegative patients with ...

background hepatitis b virus (hbv) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (hcc). hb vaccination is an essential step in the prevention of the disease and its consequent complications. objectives immune status of medical personnel in teaching hospitals of khuzestan is not well known. since these personnel are usually at risk of needle stick and other...

We evaluated the immunogenicity and reactogenicity of diphtheria, tetanus, whole-cell pertussis and hepatitis B (DTPw-HB) combination vaccine manufactured by Shantha Biotechnics Pvt Ltd, Hyderabad, India in healthy infants between 6 and 8 weeks of age. Overall 123 infants (male:female ratio, 1:1.3) were recruited, of which 112 received all three doses of the vaccine at 6, 10 and 14 weeks of age...

OBJECTIVE To provide global policy-makers with decision-making information for developing strategies for immunization of infants with a birth dose of hepatitis B vaccine, this paper presents a retrospective cost analysis, conducted in Indonesia, of delivering this vaccine at birth using the Uniject prefill injection device. METHODS Incremental costs or cost savings associated with changes in ...

The significance of a delayed type hypersensitivity skin reaction to hepatitis B surface antigen (HBsAg) (HBs-DTH) in type B viral hepatitis (VHB) and in intradermal hepatitis B (HB) vaccination is reviewed. HBs-DTH could be developed by the intradermal injection of HB vaccine in anti-HBs positive people and also in persons immunized with HB vaccine. Thus, HBs-DTH could serve as a useful marker...