Fetal hemoglobin (Hb F) may increase in patients receiving chemotherapeutic drugs, a result of potential use in patients with symptomatic hemoglobinopathies. We examined Hb F in 13 patients with myeloproliferative disease (six polycythemia vera, five polycythemia vera with myeloid metaplasia, one agnogenic myeloid metaplasia, and one chronic myelogenous leukemia) who were treated with hydroxyur...

Hb F levels were determined on samples from 750 normal blood donors. Six individuals (0.8%) had Hb F levels in excess of 1.1%, the upper end of the continuous distribution. Eight individuals at the upper end and 7 individuals at the lower end of the range were selected for family studies. These studies revealed that the control of Hb F levels in adults, as judged by the more sensitive F-cell te...

Several polypeptide growth factors related to epidermal growth factor (EGF) have been identified recently, including transforming growth factor-alpha (TGF-alpha), amphiregulin (AR), heparin-binding EGF-like growth factor (HB-EGF), and betacellulin (BTC). These peptides all bind to the EGF receptor (EGFr). In an effort to understand redundancy within this peptide family and interactions among th...

To the Editor: Glycohemoglobin assays are important for evaluating long-term glycemic control in patients with diabetes (1 ). Ion-exchange HPLC is commonly used for measuring hemoglobin A1c (Hb A1c), but hemoglobin variants (Hb) or increased fetal Hb concentrations may affect the quantification of Hb A1c by HPLC. The presence of Hb or high Hb F concentrations can be recognized by the separate e...

We present near-infrared (observed frame) spectra of the high-redshift quasar S4 0636]68 at z\ 3.2, which was previously thought to be one of a group of ““ strong ÏÏ Fe II emitters [i.e., F(Fe II jj4434È 4684)/F(Hb)[ 1]. Our K-band spectrum clearly shows emission lines of Hb and [O III] jj4959, 5007, as well as optical Fe II emission. Our computed value of F(Fe II jj4434È4684)/F(Hb) ^ 0.8 for S...

BACKGROUND Previously published data have demonstrated that sickle red blood cells produce twice as much reactive oxygen species (ROS) suggesting that co-inheritance of sickle cell disease (SCD) and glucose 6-phosphate dehydrogenase (G6PD) enzymopathy could lead to more severe anaemia during sickling crises. Elevated foetal haemoglobin (Hb F) levels have been shown to have positive modulatory e...

A 52-year-old woman with a medical history of hepatitis B, hyperlipidemia, hypertension, anemia, and depression presented to the internal medicine clinic for a routine visit. Laboratory tests 3 months previously had revealed an impaired fasting glucose concentration of 5.9 mmol/L (106 mg/dL) [reference interval, 3.9 –5.6 mmol/L (70 –100 mg/dL)]. Therefore, a hemoglobin (Hb) A1c analysis was per...

I N A ROUTINE SURVEY OF HEMOGLOBINS in patients at the Veterans Administration Hospital at Augusta, Georgia, an elevated amount of hemoglobin F (Hb-F) was observed in a Caucasian male. This individual had been repeatedly admitted for orthopedic treatment of a war injury and not because of any hematologic problem. Subsequent investigation determined that the condition was inherited and that the ...

Bowel endoscopy referrals from primary care have increased steadily over recent years. However, most patients do not have significant colorectal disease (SCD). Therefore, strategies to select those who would benefit most from endoscopy are of current interest. A recent study developed a multivariable diagnostic model for SCD with routine clinical information, extended with quantitative faecal c...

THE AMOUNT OF FETAL HEMOGLOBIN (HB F) IN ERYTHROCYTES OF PATIENTS WITH SICKLE CELL ANEMIA (HB SS DISEASE) WAS MEASURED BY TWO METHODS: (a) photometry of individual cells stained for Hb F by the Kleihauer-Betke technique; and (b) chemical assay of alkali-resistant hemoglobin in cells distributed according to specific gravity by ultracentrifugation. Irreversibly sickled cells (ISC), which could b...