we have found prefabrication of hairless radial forearm free flap to be a useful technique for nasal reconstruction. prior skin grafting and a suitable period of maturation permits safe, reliable surgery. its use should be considered in those patients whose forehead tissue is not suitable or in whom appropriate distant flaps are not available, as is often the case with hirsute males.

The divergence in phenotype and habitat preference within the crested newt Triturus cristatus superspecies, examined across different ontogenetic stages, provides an excellent setting to explore the pattern of adaptive radiation. The crested newts form a well-supported monophyletic clade for which at least the full mitochondrial DNA phylogeny is resolved. Here we summarise studies that explored...

Cell fate choices during metazoan development are driven by the highly conserved Notch signalling pathway. Notch receptor activation results in release of the Notch intracellular domain (NICD) that acts as transcriptional co-activator of the DNA-binding protein CSL. In the absence of signal, a repressor complex consisting of CSL bound to co-repressors silences Notch target genes. The Drosophila...

Daniel T. Blumstein,a,b Matthew B. Petelle,a and Tina W. Weyc aDepartment of Ecology and Evolutionary Biology, University of California, 621 Young Drive South, Los Angeles, CA 90095–1606, USA, bThe Rocky Mountain Biological Laboratory, PO Box 519, Crested Butte, CO 81224, USA, and cDepartment of Environmental Science and Policy, University of California, Davis, One Shields Avenue, Davis, CA 956...

We demonstrate the capability of nonlinear spectral imaging microscopy (NSIM) in investigating ultraviolet and visible light induced effects on albino Skh:HR-1 hairless mouse skin non-invasively.

Atrichia with papular lesions is a rare form of total alopecia, in which mutations in the hairless gene have been shown to underlie the phenotype. In the literature to date, atrichia with papular lesions has generally been reported to be inherited in an autosomal recessive manner. A few rare cases exist, however, in which parent-to-child transmission of atrichia with papular lesions has been do...