BACKGROUND Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not available. OBJECTIVE The primary obj...

Some genetically determined traits, such as ear lobes, finger hair and hairy car were studied in 89 schizophrenic patients and compared with normals. The proportion of schizophrenic males having earlobes hanging free was much less than the control group. This difference is highly significant statistically (p < .0001). Similar was our observation in schizophrenic females (p < .05). Furthermore n...

S cience rarely allows the " is " —the way the world is—to become the " ought " of the way we think it should be. However, one particular aspect of modern biology may be of interest in this respect, namely, the history of our own genetic inheritance. As has been so often said, human evolution is the greatest story in history. We will use our own work on red hair and skin type genetics as an exa...

In this review article we summarize current knowledge on how variation on the DNA level influences human pigmentation including color variation of iris, hair, and skin. We review recent progress in the field of human pigmentation genetics by focusing on the genes and DNA polymorphisms discovered to be involved in determining human pigmentation traits, their association with diseases particularl...

Hair color is one of the most visible and heritable traits in humans. Here, we estimated heritability by structural equation modeling (N = 20,142), and performed a genome wide association (GWA) analysis (N = 7091) and a GCTA study (N = 3340) on hair color within a large cohort of twins, their parents and siblings from the Netherlands Twin Register (NTR). Self-reported hair color was analyzed as...

Genome-wide association studies (GWAS) to date have discovered thousands of genetic variants linked to human diseases and traits, which hold the potential to unravel the mechanisms of complex phenotypes. However, given that the majority of these associated variants reside in non-coding genomic regions, their predicted and -regulatory functions remain largely undefined. cis trans Here we show th...

Root traits associated with resource foraging, including fine-root branching intensity, root hair, and mycorrhiza, may change in soils that vary rock fragment content (RFC), while how these covary at the level of individual order is largely unknown. We subjected two xerophytic species, Artemisia vestita (subshrub) Bauhinia brachycarpa (shrub), to increasing RFC gradients (0%, 25%, 50%, 75%, v v...

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers. Methods: This prospective controlled clinical trial compares the current acknowledged form of treatment for hair loss within two controlled groups for both m...

Suboptimal availability of water and nutrients is a primary limitation to plant growth in terrestrial ecosystems. The acquisition of soil resources by plant roots is therefore an important component of plant fitness and agricultural productivity. Plant root systems comprise a set of phenes, or traits, that interact. Phenes are the units of the plant phenotype, and phene states represent the var...

BACKGROUND Various trials have been conducted on the management of male pattern hair loss (MPHL). A variety of laser and light sources have been used for the treatment of MPHL. OBJECTIVE To understand the effects of a 1,550-nm fractional erbium-glass laser on the hair cycle in an alopecia mouse model and to study the clinical effects of the same laser used as treatment for MPHL. MATERIALS A...