Very little is known about the role of histone H3 phosphorylation in malignant transformation and cancer development. Here, we examine the function of H3 phosphorylation in cell transformation in vivo. Introduction of small interfering RNA-H3 into JB6 cells resulted in decreased epidermal growth factor (EGF)-induced cell transformation. In contrast, wild-type histone H3 (H3 WT)-overexpressing c...

AIMS Hepatic stellate cells (HSCs) play critical roles in the development of hepatic fibrosis caused by various agents including alcohol. Ethanol causes post-translational modification in histone. The goal of this study is to investigate whether ethanol affected acetylation and methylation of histone H3 in rat HSCs. METHODS We isolated and separated HSCs using collagenase perfusion of liver f...

AbstractObjective To identify physical activity barrier prevalence and severity among manual wheelchair users (MWCUs) test whether impact is associated with self-reported level (PAL). Design Cross-sectional survey. The Barriers to Physical Activity Questionnaire for People Mobility Impairments (BPAQ-MI) was translated from English Danish administered online. BPAQ-MI i...

Summary Aim: In winegrape production, pruning, canopy management, and harvest are essential practices that increasingly being done by machines. How well these executed can substantially affect fruit yield quality. Mechanization offers timeliness, uniformity, cost benefits, but most methods available to date nonselective optimal execution requires careful attention vineyard des...

Introduction: The objective of this study was to assess the 11-year mortality risk methicillin-resistant Staphylococcus aureus (MRSA) colonization in community-dwelling adults aged 40 85 years. Methods: analyzed National Health and Nutrition Examination Survey (NHANES) 2001 2004 linked Death Index through December 31, 2015. Our cohort community years 6085 participants (...

Introduction: Preventing and ending homelessness for women veterans, a priority of the Department Veterans Affairs (VA), can be aided by identifying factors that increase their risk housing instability. Methods: This study relied on data from Health Administration9s universal screen instability Fiscal Year 2013 to 2016, administrative electronic medical records. Using logistic...

Introduction/Background* The breast is the most common site of primary malignancies in adult women, but an uncommon for metastasis from extramammary malignancies. Breast metastases have both hematogenous and lymphatic routes. We report 10 cases our pathology lab between 2014 2020. Methodology identified all diagnosed Result(s)* found extra mammary All patients was fem...

The chicken H3 histone gene family contains nine members belonging to two major histone gene clusters. Six of these genes have been sequenced and shown to encode two different H3 protein variants. Five H3 genes (H3-I, -II, -IV, -V, and -VI) encode the same amino acid sequence (class I) and another H3 gene (H3-III) differs from class I in a single amino acid (IIe113-Met) (class II). H3-II and H3...

BACKGROUND Members of the B7 superfamily costimulate the proliferation of lymphocytes during the initiation and maintenance of antigen-specific humoral and cell-mediated immune responses. B7-H3 (CD276) is a newly identified member of the B7 superfamily. It has been shown that B7-H3 plays a significant role in regulating T cell response in humans and mice, but it is not known whether a counterpa...