• Monoclonal antibody blockade of the common gamma chain attenuates acute and chronic GvHD. • Common gamma chain cytokines increase granzyme B levels in CD8 T cells, which is reduced upon CD132 blockade in vivo. Abstract The common gamma chain (CD132) is a subunit of the interleukin (IL) receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Because levels of several of these cytokines were sh...

Background: Based on the dynamics of antigen recognition from T cell receptor complex and T cell activation, different function of T cells may present different morphology feature, at least at molecular level. Regulatory T (Treg) cells play a critic role in regulation the onset of graft versus host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Little is kn...

Graft-versus-host disease(GVHD) is currently encountered following bone marrow transplantation and transfusion. GVHD associated with transfusion(TA-GVHD) in apparently immunocompetent recipients has been recently reported with increasing frequency. A consistent finding in many of these cases is that the recipient received blood from a donor homozygous for one of the the recipient's HLA haplotyp...

STAT4 and STAT6 are transcription factors that play crucial roles in responding to IL-12 and IL-4, respectively. STAT4 gene knockout (STAT4(-/-)) mice have markedly reduced Th1 responses and enhanced Th2 responses. STAT6(-/-) mice show the inverse phenotype. We compared the ability of bone marrow transplantation (BMT) with the inclusion of spleen cells from STAT6(-/-), STAT4(-/-), and wild-type...

Recently, Bucher et al. addressed rational graft-versushost disease (GVHD) prophylaxis (December 2012 issue of this Journal). The authors addressed calcineurin inhibition and T-cell immune modulation but fully overlooked the important results obtained with rituximab that have been reported in the prevention of acute and chronic GVHD. Initial reports on the potential role of rituximab in chronic...

Recognized manifestations of acute graft-versus-host disease (GVHD) of the gastrointestinal (GI) tract include secretory diarrhea, abdominal pain, and, at times, hemorrhage. In a review of 469 patients undergoing allogeneic bone marrow transplantation (BMT) from matched sibling donors at our institution, we have recognized a syndrome of upper GI GVHD. This syndrome, presenting clinically as ano...

This paper attempts to predict the onset of chronic Graft vs. Host Disease (GVHD) in children with blood cancers who have received a bone marrow or stem cell transplant using machine learning models. It analyzes and compares results three different models terms how accurate they each are predicting GVHD. These Logistic Regression, J48 algorithm decision trees, Multilayer Perceptron. The formed ...

Methotrexate (MTX) is one of the main therapeutic agents currently used for prophylaxis graft-versus-host disease (GvHD) following hematopoietic stem cell transplantation. However, it associated with significant toxicity and considerable side effects in many patients, which lead to either early withdrawal or dose reductions that may expose patients risk GvHD graft failure. Folinic acid (FA) can...

We have analyzed the long term outcome of 197 patients who were treated for grade II to IV acute graft-versus-host disease (GVHD) following histocompatible allogeneic bone marrow transplantation (BMT). Of 469 recipients of sibling donor allografts performed at our center between January, 1979 and October, 1987, 197 patients (42%) developed greater than or equal to grade II acute GVHD at a media...

PURPOSE In this study, we analyzed a cohort of children with chronic graft-versus-host disease (GvHD) according to the NIH consensus classification (NCC) in order to observe whether global assessment at diagnosis correlates with GvHD-specific endpoints. We then studied the clinical course of these patients, specifically with regards to episodes of GvHD exacerbation requiring treatment escalatio...