This study was designed to evaluate the therapeutic effect of 70% ethanolic crude extract of Portulaca oleracea L on mice mammary adenocarcinoma (in vivo). In vivo, the acute toxicity of 70 % ethanolic extract of the plant on normal mice has been studied. No toxic effect was noticed on normal mice even at 9500 mg /kg B.W S/C injection. Therapeutic effect of ethanolic extract of Portulaca olerac...

BACKGROUND In radiation oncology recurrence analysis is an important part in the evaluation process and clinical quality assurance of treatment concepts. With the example of 9 patients with locally advanced pancreatic cancer we developed and validated interactive analysis tools to support the evaluation workflow. METHODS After an automatic registration of the radiation planning CTs with the f...

This paper presents an improved GrowCut (IGC), a positron emission tomography-based segmentation algorithm, and tests its clinical applicability. Contrary to the traditional method that requires the user to provide the initial seeds, the IGC algorithm starts with a threshold-based estimate of the tumor and a three-dimensional morphologically grown shell around the tumor as the foreground and ba...

PURPOSE To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer and inter-modality variability. METHODS Nineteen patients with anal cancer undergoing chemoradiotherapy were prospectively included. Planning computed tomography (CT) images were co-registered with 18F-fluorodexocyglucose (FDG...

PURPOSE Using magnetic resonance imaging (MRI), residual tumor cannot be differentiated from nonspecific postoperative changes in operated patients with brain gliomas. The higher specificity and sensitivity of L-(methyl-11C)-labeled methionine positron emissions tomography (MET-PET) in gliomas has been demonstrated in previous studies and is the rationale for the integration of this investigati...

objective(s): this study aimed to evaluate the role of pretreatment suvmax and volumetric fdg positron emission tomography (pet) parameters in the differentiation between benign and malignant mediastinal tumors. in addition, we investigated whether pretreatment suvmax and volumetric fdg-pet parameters could distinguish thymomas from thymic carcinomas, and low-risk from high-risk thymomas.method...

Magnetic resonance imaging (MRI) is a crucial tool for clinical brain tumor detection and delineation. Since the process of gross tumor volume delineation resides with clinicians, a better understanding of how they perform this task is required if improvements in life expectancy are to be made. Novice-expert comparison studies have been used to examine the effect of expertise on abnormality det...

STUDY OBJECTIVE A prospective study was undertaken to assess the efficacy and toxicity of conformal proton-beam radiotherapy for early-stage, medically inoperable non-small cell lung cancer. DESIGN Eligible patients had clinical stage I to IIIa non-small cell lung cancer and were not candidates for surgical resection for medical reasons or because of patient refusal. Patients with adequate ca...

Proton relative biological effectiveness (RBE) is known to depend on the (α/β)x of irradiated tissues, with evidence of ∼60% variation over (α/β)x values from 1-10 Gy. The range of (α/β)x values reported for prostate tumors (1.2-5.0 Gy), brain tumors (10-15 Gy) and liver tumors (13-17 Gy) imply that the proton RBE for these tissues could vary significantly compared to the commonly used generic ...

PURPOSE To assess changes in the volumes and spatial locations of tumors and surrounding organs by cone beam computed tomography during treatment for cervical cancer. MATERIALS AND METHODS Sixteen patients with cervical cancer had intensity-modulated radiotherapy and off-line cone beam computed tomography during chemotherapy and/or radiation therapy. The gross tumor volume (GTV-T) and clinica...