چکیده: در ایـن مقاله طراحی یک مبدل زمان به دیجیتال 12 بیتی رزولوشن بالا و توان مصرفی کم مبتنی بر اسیلاتور حلقوی چند­مسیره (multi-path gated ring oscillator) در تکنولوژی nm-cmos130 بیان شده است. برای افزایش رزولوشن دو مسیر گیت با رزولوشن­های متفاوت، رزولوشن درشت و رزولوشن ریز، به­صورت ساختار ورنیر استفاده شده است. تأخیر گیت هر مسیر تعیین­کننده رزولوشن آن مسیر و به دلیل به ­کار بردن آن­ها در ساخت...

Mesenchymal stem/stromal cells (MSCs) are promising potential candidates for the treatment of immunological diseases because of their immunosuppressive functions. However, the molecular mechanisms that mediate MSCs' immunosuppressive activity remain elusive. In this article, we report for the first time, to our knowledge, that secreted growth-regulated oncogene (GRO) chemokines, specifically GR...

GRO J1655-40 is a transient black-hole candidate that has been shown to eject matter at apparently superluminal velocities. OSSE spectra measured during X-ray outbursts are consistent with a single power law up to 600 keV, with no evidence for a high-energy cutoo. Flaring behaviour of GRO J1655-40 has also been claimed to be detected up to 10 MeV during observations with the balloon-borne HIREG...

Non-muscle invasive bladder cancers (NMIBC) are typically treated by transurethral resection with intravesical chemotherapy. However, the post-therapeutic incidence of tumor recurrence and progression to muscle invasive disease is high, and the underlying mechanism(s) remains unknown. In this study, we observed that recurrent bladder cancer cells exhibit a mesenchymal phenotype, which is initia...

Growth-regulated oncogene-alpha (GRO-α) has been reported to be over-expressed in a series of human cancers including colorectal cancer, melanoma, gastric cancer, hepatocellular carcinoma, and ovarian cancer and was known to regulate multiple biologic activities associated with tumor progression. But the role in human pancreatic cancer remains unclear. To examine the expression of GRO-α and its...

At inflammatory sites in vivo, leukocytes may confront multiple, competing chemoattractive signals. We found significant differences between eosinophils and neutrophils in transendothelial chemotaxis to a chemoattractant diffusing from the lower chamber, when a chemoattractant that binds to another receptor is present at uniform concentration. The transendothelial migration of eosinophils to FM...

Se analiza si la orientación del rol de género (GRO) y percepción cultura emprendedora afectan en el avance las etapas proceso emprendedor mujeres. Considerando una muestra 1.195 mujeres españolas, se utilizan escalas test roles sexuales Bem regional percibida. Los resultados confirman que con masculina o andrógina tienen más probabilidades emprender; y, para GRO masculinas, su región fomenta e...

Patterning of the non-segmental termini of the Drosophila embryo depends on signalling via the Torso receptor tyrosine kinase (RTK). Activation of Torso at the poles of the embryo triggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb). In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the...

The Groucho (Gro)/transducin-like enhancer of split family of transcriptional corepressors are implicated in many signalling pathways that are important in development and disease, including those mediated by Notch, Wnt and Hedgehog. Here, we describe a genetic screen in Drosophila that yielded 50 new gro alleles, including the first protein-null allele, and has two mutations in the conserved Q...

Introducing alternative cultivars with enhanced water use efficiencies can help alleviate pressure on groundwater for crop irrigations in Mississippi (MS) Delta. A two-year field study was conducted 2019–2020 to compare the (WUE) of recently released and pre-released soybean {Glycine max (L.) Merr.} maturity group (MG) III (‘P37A78’, ‘LG03-4561-14’), IV (‘Dyna-gro 4516x’, ‘DS25-1, DT97-4290’), ...