Low concentrations of the antibiotic griseofulvin were found to cause increased frequencies of somatic segregation due to chromosome nondisjunction in a diploid strain of Aspergillus nidulans.

Random-bred infant Swiss mice were injected subcutaneously with suspensions of griseofulvin in tricaprylin according to various dosage schedules. Doses of griseofulvin in excess of 0.25 mg on Day 1 of life produced acute toxicity. Following a total dosage of 3.0 mg in infant mice. 0.5, 0.5, 1.0, and 1.0 mg at ages of 1, 7, 14, and 21 days, respectively, a high incidence of hepatomata, in 44% of...

The sensitivity of early preimplantation mouse embryos to drugs which disrupt microfilament function (cytochalasin B-CB and cytochalasin D-CD and microtubule assembly (colchicine, colcemid, vinblastine and griseofulvin) was examined. CD inhibited cleavage at a concentration 35-fold lower than CB (3 X 10-7 M v. 1 X 10-5 M). Treatment of 2-cell embryos for 6 h with 1 X 10-5 M CB or 1 X 10-6 M CD...

Hebeka, Elias K. (Rutgers, The State University, New Brunswick, N.J.), and Morris Solotorovsky. Development of resistance to polyene antibiotics in Candida albicans. J. Bacteriol. 89:1533-1539. 1965.-Strains of Candida albicans resistant to the polyenes candidin and amphotericin B, but not to nystatin, were developed by sub-culturing the organism in gradually increasing concentrations of the an...