Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may contribute to AM toxicity. Apoptotic cell death in nontransformed human peripheral lung epithelial 1A (HPL1A) cells was assessed by annexin V-fluorescein isothiocyanate (ann-V) staining and terminal deoxynucleotidyl transferase-m...

BACKGROUND Dog erythrocyte antigen (DEA) 1.1 is the most important RBC antigen clinically, as it is highly immunogenic and causes acute hemolytic transfusion reactions (HTR) in sensitized dogs. OBJECTIVES The aims of this study were to determine the frequency of DEA 1.1 expression in 4 Turkish dog breeds, and to estimate the potential risk of HTR when blood from a DEA 1.1-positive donor is ad...

This paper proposes a new efficiency benchmarking methodology that is capable of incorporating probability while still preserving the advantages of a distribution-free and nonparametric modeling technique. This new technique developed in this paper will be known as the DEA-Chebyshev model. The foundation of DEA-Chebyshev model is based on the model pioneered by Charnes, Cooper, and Rhodes in 19...

In Chen, Cook, Kao, and Zhu (2013), it is demonstrated, as a network DEA pitfall, that while the multiplier and envelopment DEA models are dual models and equivalent under the standard DEA, such is not necessarily true for the two types of network DEAmodels in deriving divisional efficiency scores and frontier projections. As a reaction to this work, we demonstrate that the duality in the stand...

Data Envelopment Analysis (DEA) is the most commonly used approach for evaluating healthcare efficiency (Hollingsworth, 2008), but a long-standing concern is that DEA assumes that data are measured without error. This is quite unlikely, and DEA and other efficiency analysis techniques may yield biased efficiency estimates if it is not realized (Gajewski, Lee, Bott, Piamjariyakul and Taunton, 20...

In humans, cytochrome P450 3A (CYP3A4) is a major enzyme involved in the metabolism of amiodarone (AM) to its major metabolite, desethylamiodarone (DEA). In rat, a commonly used animal model, metabolism of AM has not been well studied. To determine whether DEA is formed by CYP3A isoenzymes in the rat, microsomal protein was harvested from liver and intestine of male Sprague-Dawley rats. The met...

in recent years, the problem of selecting and evaluating the suppliers in supply chain management has aroused considerable interest in business firms. owing to the development of information systems, reaching an appropriate decision for adopting discrete methods is a need. the researchers intend to present a new model in this paper as a contributing factor in the grey environment in which the r...

The spectroscopic and electrochemical properties of a series of four RuII polypyridyl complexes are reported. Compounds of the form [Ru(dmb)x(dea)3-x] (x ) 0-3), where dmb is 4,4′-dimethyl-2,2′-bipyridine and dea is 4,4′-bis(diethylamino)-2,2′-bipyridine, have been prepared and studied using static and time-resolved electronic and vibrational spectroscopies as a prelude to femtosecond spectrosc...

An algorithm stral:egy is proposed for use with the assurance region (AR) approach in data envelopment analysis (DEA). The strategy addressed in this study characterizes and cla.5sifies all decision making units (DMUs) into several subsets, using the revised simplex method of linear programming. Then, each DMU subset is solved by a different algorithm. Experimental studies consisting of randoml...

In many data envelopment analysis (DEA) applications, the analyst always confronts the difficulty that the selected data set is not suitable to apply traditional DEA models for their poor discrimination. This paper presents an approach using Shannon’s entropy to improve the discrimination of traditional DEA models. In this approach, DEA efficiencies are first calculated for all possible variabl...