Immune-checkpoint inhibitors (ICIs) such as pembrolizumab and nivolumab have transformed oncologic therapeutic modalities. By disrupting tumor-induced immunosuppression, ICIs facilitated effective treatment of numerous malignancies, including metastatic melanoma; however, due to the ensuing disturbance immune system, various immune-mediated adverse reactions been reported with ICI therapy. We p...

A 55 year old female came to Skin OPD with extensive pruritic annular papules and plaques over both upper limbs, lower limbs, back and abdomen. Biopsy from one of the lesion confirmed histopathologiclly Granuloma annulare. This case is being presented for its extensive skin involvement without any systemic disorder.

Generalized granuloma annulare (GGA) is a rare benign granulomatous dermatosis characterized by disseminated necrobiotic dermal papules. Histologically, it presents as a lymphohistiocytic granuloma associated with varying degrees of connective tissue degeneration. It usually occurs in adults and rarely affects infants. Herein, we report an interesting case of GGA which occurred in a 3 month-old...

To cite: Mestre T, Rodrigues AM, Cardoso J. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-205883 DESCRIPTION Granuloma annulare is a granulomatous skin disease of unknown aetiology. It is more common in women and has a disseminated form in 10–15% of patients. A small portion of these patients have an associated disease such as diabetes mellitus, viral infe...

OBJECTIVES To characterize human immunodeficiency virus (HIV)-associated granuloma annulare (GA) by clinical, microscopic, and molecular methods and to investigate the role of Epstein-Barr virus infection in the pathogenesis of GA. DESIGN Patients were evaluated clinically, and biopsy specimens of lesional skin were examined by light microscopy. Polymerase chain reaction and in situ hybridiza...

Granuloma annulare has been associated with systemic disease including diabetes mellitus. We report a case of a 62-year-old Japanese woman with generalized erythematous granuloma annulare who showed remission after substantial improvement in hyperlipidemia following a strict lipid-lowering diet. The lesion appeared in the lower abdomen one year before current presentation and subsequently sprea...

OBJECTIVE To familiarize surgeons to the natural history and treatment of granuloma annulare of the extremities in children. DESIGN Case review and follow-up by appointment and questionnaire. SETTING The Children's Hospital of Eastern Ontario, a tertiary referral centre. PATIENTS Twenty-seven children (23 girls, 4 boys) seen between 1983 and 1998 with subcutaneous granuloma annulare, prov...

We here report the case of Mrs A.S, aged 29, with no particular past medical history, presenting with asymptomatic papules on the back of hands evolving for 3 months. The patient reported she hadn’t taken drugs, she hadn’t been bitten by an insect, she had no arthralgias and she showed no signs of connectedness. Clinical examination showed painless, nonpruritic rounded sometimes erythematous an...

Granuloma Annulare is an flammatory bening skin disease that may manifest different clinical features.the most common presentation or classic form of the disease is fleshcolor,annulare,grouped papules,disseminated forms are rare and responses to treatments are vnot satisfactory.various treatment modalities have been used for this disorder and different responses to treatments have been reported...