نتایج جستجو برای: gpi

تعداد نتایج: 4043  

2015
Gianni Guizzunti Chiara Zurzolo

We previously reported that PrP GPI-anchor signal peptide (GPI-SP) is specifically degraded by the proteasome. Additionally, we showed that the point mutation P238S, responsible for a genetic form of prion diseases, while not affecting the GPI-anchoring process, results in the accumulation of PrP GPI-SP, suggesting the possibility that PrP GPI-anchor signal peptide could play a role in neurodeg...

Journal: :Blood 2003
Anastasios Karadimitris David J Araten Lucio Luzzatto Rosario Notaro

A most distinctive feature of paroxysmal nocturnal hemoglobinuria (PNH) is that in each patient glycosylphosphatidylinositol-negative (GPI-) and GPI+ hematopoietic stem cells (HSCs) coexist, and both contribute to hematopoiesis. Telomere size correlates inversely with the cell division history of HSCs. In 10 patients with hemolytic PNH the telomeres in sorted GPI- granulocytes were shorter than...

2012
David M. McKean Lee Niswander

Holoprosencephaly is the most common forebrain defect in humans. We describe two novel mouse mutants that display a holoprosencephaly-like phenotype. Both mutations disrupt genes in the glycerophosphatidyl inositol (GPI) biosynthesis pathway: gonzo disrupts Pign and beaker disrupts Pgap1. GPI anchors normally target and anchor a diverse group of proteins to lipid raft domains. Mechanistically w...

Journal: :Organization & Environment 2022

Green product innovation (GPI) is a cornerstone of environmental management. Recent reviews on GPI have shown that research antecedents has mainly focused identifying specific factors influencing the use GPI. However, most studies lack comprehensive theoretical explanation findings. In this study, which based sample 303 Swedish small manufacturing firms, to are examined using attention-based vi...

Journal: :Journal of leukocyte biology 2000
Y Nakamura-Sato K Sasaki H Watanabe Y Araki F Sendo

We previously reported a novel glycosylphosphatidylinositol (GPI)-anchored glycoprotein (tentatively designated GPI-80) on human leukocytes that may be involved in the regulation of neutrophil adherence and migration. In this study, we examined by immuno- and scanning electron microscopy, the distribution of GPI-80 on neutrophil surfaces. GPI-80 was diffusely distributed on the surface of resti...

Journal: :Cell 2004
Pranav Sharma Rajat Varma R. C Sarasij Ira Karine Gousset G Krishnamoorthy Madan Rao Satyajit Mayor

Cholesterol and sphingolipid-enriched "rafts" have long been proposed as platforms for the sorting of specific membrane components including glycosyl-phosphatidylinositol-anchored proteins (GPI-APs), however, their existence and physical properties have been controversial. Here, we investigate the size of lipid-dependent organization of GPI-APs in live cells, using homo and hetero-FRET-based ex...

Journal: :Journal of cell science 2014
Manuel Muñiz Chiara Zurzolo

Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are luminal secretory cargos that are attached by a post-translational glycolipid modification, the GPI anchor, to the external leaflet of the plasma membrane. GPI-APs are conserved among eukaryotes and possess many diverse and vital functions for which the GPI membrane attachment appears to be essential. The presence of the GPI anc...

Journal: :Blood 1998
G Civenni S T Test U Brodbeck P Bütikofer

In many different cells, glycosylphosphatidylinositol (GPI)-anchored molecules are clustered in membrane microdomains that resist extraction by detergents at 4 degrees C. In this report, we identified the presence of such domains in human erythrocytes and examined the ability of exogenously-added GPI-anchored molecules to colocalize with the endogenous GPI-anchored proteins in these detergent-i...

Journal: :Infection and immunity 1997
N Garg M Postan K Mensa-Wilmot R L Tarleton

Induction of a glycosylphosphatidylinositol (GPI) deficiency in Trypanosoma cruzi by the heterologous expression of Trypanosoma brucei GPI-phospholipase C (GPI-PLC) results in decreased expression of major surface proteins (N. Garg, R. L. Tarleton, and K. Mensa-Wilmot, J. Biol. Chem. 272:12482-12491, 1997). To further explore the consequences of a GPI deficiency on replication and differentiati...

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