نتایج جستجو برای: gossypol

تعداد نتایج: 670  

Journal: :Journal of animal science 1998
J Velasquez-Pereira L R McDowell C A Risco D Prichard F G Martin M C Calhoun S N Williams N S Wilkinson P Ogebe

We conducted an experiment for 112 d with yearling beef heifers to evaluate the effects of cottonseed meal (CSM) fed with various concentrations of vitamin E on hematological and tissue components. Heifers were assigned randomly to four treatments, with eight heifers per treatment. The treatments consisted of the following dietary supplements: 1) CON, based on soybean meal with 30 IU vitamin E/...

2004
A. S. EL-SHARAKY

The fatty acids pattern of the total lipid fractions of male rat serum and seminal fluids were studied under the effect of gossypol and some of its metabolites (Apogossypol and gossypolone). The applied dose of gossypol and its derivatives exhibits some metabolic effects such as significant decrease of the saturated fatty acids and a significant increase of polyunsaturated fatty acids. In the s...

2014
Q. F. Zeng G. L. Yang G. N. Liu J. P. Wang S. P. Bai X. M. Ding Y. H. Luo K. Y. Zhang

The objective of this study was to determine the effects of gossypol from cottonseed meal (CSM) on growth performance, blood biochemical profiles, and liver histopathology of ducks. A total of 900 1-d-old ducks were randomly allocated to 5 treatments with 12 pens/treatment and 15 ducks/pen. The 5 experimental diets were formulated in such a way that 0% (a corn-soybean meal basal diet, diet 1), ...

Journal: :Journal of materials chemistry. B 2014
Hao Liu Ke Li Lan Lan Jingwen Ma Yun Zeng Liang Xu Daocheng Wu

This study aimed to enhance the water solubility and antitumor efficacy of (-)-gossypol. Polyethyleneimine conjugated with stearic acid (PgS) was used for loading and protecting (-)-gossypol through hydrogen bonding. Double-layered hyaluronic acid (HA)-modified PgS nanoparticles encapsulating (-)-gossypol [(-)-G-PgSHAs] were prepared through a two-step fabrication process. The nanoparticles pos...

Journal: :Biochemical and biophysical research communications 1984
A de Peyster A Quintanilha L Packer M T Smith

Gossypol, a polyphenolic compound found in cotton plants, has many potential uses, including use as a male antifertility drug and spermicide. Gossypol affects a variety of cell processes and many of these effects may be explained by a common underlying mechanism. Here we report that gossypol promotes the formation of oxygen radicals when incubated with rat liver microsomes and human sperm sugge...

2015
CAI-LING JIN MEI-LING CHEN YING WANG XIAO-CHUN KANG GUANG-YE HAN SU-LING XU

The aim of the present study was to investigate the antitumor effects and possible mechanism of (-)-gossypol nanoparticles, loaded with vv polyethylene glycol-maleimide (mPEG-Mal), in vitro. Emulsification-volatilization was used to prepare the loaded (-)-gossypol nanoparticles. The toxicity of blank nanoparticles on human prostate cancer PC-3 cells and human prostate RWPE-1 cells was measured....

Journal: :Cancer research 1990
J W Jaroszewski O Kaplan J S Cohen

The action of gossypol, a polyphenolic bisnaphthalene aldehyde, on a number of drug-sensitive and multidrug-resistant cell lines, in particular MCF-7 WT and MCF-7 ADR cells, was studied and compared to the effects of rhodamine 123. 31P nuclear magnetic resonance spectra of cells exposed to low concentrations of gossypol exhibited decreased levels of ATP, markedly increased levels of pyridine nu...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Christopher L Oliver Joshua A Bauer Keith G Wolter Mathew L Ubell Ajita Narayan Kathleen M O'Connell Susan G Fisher Shaomeng Wang Xihan Wu Min Ji Thomas E Carey Carol R Bradford

PURPOSE Bcl-xL overexpression is common in head and neck squamous cell carcinomas (HNSCC) and correlates with resistance to chemotherapy. Thus, a nonpeptidic, cell-permeable small molecule that mimics the BH3 domain of proapoptotic proteins may inhibit Bcl-xL function and have therapeutic potential for HNSCC by overcoming drug-resistance. (-)-Gossypol, the levorotatory isomer of a natural produ...

Journal: :Plant physiology 1968
D D Killion S Grooms R E Frans

Mitochondria isolated from 2 strains of cotton plant hypocotyls (Gossypium hirsutum L. var. Rex smooth leaf and Rex glandless) were examined for their oxidative phosphorylation activities. Bovine serum albumin at a relatively high concentration was essential in the extraction medium for the isolation of oxidatively active mitochondria from both strains of cotton. Phosphorylation was obtained on...

Journal: :Environmental Health Perspectives 1998
B E Fisher

Gossypol, a phenolic compound extracted from the cotton plant, has been used as an oral male contraceptive in China; few side effects other than transient hypokalaemia have been reported (Qian & Wang, 1984; Prasad & Diczfalusy, 1982). Recent reports using experimental tumour models indicate that gossypol may also be a potential anti-tumour chemotherapeutic agent (Wang & Rao, 1984; Tso, 1984; Tu...

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