After 4 repeated treatrnents of gonadotrophin, 8 beef cattle showed an average of 12.1, 10.1, 12,1 and 8.4 corpora lutea at the lst, 2nd, 3rd and 4th treatments, respectively, However, different dosages of gonadotrophin ranging from 1,600 to 3,5001U of pregnant mare's serum gonadotrephin (PMSG}, were used. The average number of corpora lutea decreased from 12.4, 8,4, 9,8 and 6.0 cluring the lst...

An immunochemical procedure for routine laboratory diagnosis of pregnancy utilizing adsorption of human chorionic gonadotrophin onto kaolin and the Ortho pregnancy test reagents is described. The method is suitable for quantitative assay of urinary human chorionic gonadotrophin and can be adapted for use with serum. It was found to compare favourably with the reliability of Galli-Mainini toad t...

Cryptorchidism is common in infants born preterm, yet the mechanism for its occurrence is still debated. In a study of 21 premature babies with cryptorchidism at 18 months post-term and 21 case matched controls, cryptorchid preterm infants failed to show the normal rise in plasma testosterone in the first postnatal week. This rise is thought to relate to residual maternal human chorionic gonado...

Arecent study (Dullaart, Kent & Ryle, 1975) showed high serum gonadotrophin levels in infantile mice. Initially, the concentration ofLH and FSH rose steadily, the former reaching a peak concentration around 9 days after birth then falling by 13 days to the range found in pubertal serum. The concentration of FSH, however, continued to rise until 13 days. The rise in endogenous gonadotrophin leve...

The objective of this study was to compare the live birth rates resulting from ovarian stimulation with highly purified human menopausal gonadotrophin (HP-HMG), which combines FSH and human chorionic gonadotrophin-driven LH activities, or recombinant FSH (rFSH) alone in women undergoing IVF cycles. An integrated analysis was performed of the raw data from two randomized controlled trials that w...

Recent evidence has demonstrated that expression of leptin and leptin receptors is expected in the human ovary, and that leptin alters ovarian steroidogenesis in animal models. This study was designed to determine whether leptin modulates basal, gonadotrophin-, and insulin-stimulated progesterone production by human luteinized granulosa cells (GC). GC were recovered from follicular aspirates ob...

Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CC levels. Normal values for immunochemically reactive CC during the first trimester of pregnancy are given. Serial d...

Thirty prepubertal patients with thalassaemia major (15 boys and 15 girls) aged from 9.3 to 17.2 years (mean 12.9) who had successfully undergone allogenic bone marrow transplantation were studied. Before the transplant all patients were given short courses of high doses of busulphan (total dose 14 mg/kg) followed by cyclophosphamide (total dose 200 mg/kg). Pituitary gonadal function was assess...

Gonadotrophin-releasing hormone agonists (GnRHa) are widely used in in-vitro fertilization (IVF) for the prevention of a premature rise in luteinizing hormone (LH) concentrations. However, the administration of GnRHa during the follicular phase may also impair subsequent luteal function due to retarded recovery of pituitary gonadotrophin secretion. Therefore, luteal supplementation is generally...