INTRODUCTION Gold nanoparticles have been used as radiation dose enhancing materials in recent investigations. In the current study, dose enhancement effect of gold nanoparticles on tumor cells was evaluated using Monte Carlo (MC) simulation. METHODS We used MCNPX code for MC modeling in the current study. A water phantom and a tumor region with a size of 1×1×1 cm3 loaded with gold nanopartic...

The ultrasensitive detection of human prostate metastatic cancer cells (Du-145) was investigated through a novel electrochemical cytosensor. The proposed biosensor was simultaneously developed via two approaches: multivalent identification and signal amplification. Herein, anti-CD166 monoclonal antibody-modified gold electrode was applied to capture and recognize target cells (Du-145). Also, a ...

Over the past 10 years, polyvalent DNA-gold nanoparticle (DNA-GNP) conjugate has been demonstrated as an efficient, universal nanocarrier for drug and gene delivery with high uptake by over 50 different types of primary and cancer cell lines. A barrier limiting its in vivo effectiveness is limited resistance to nuclease degradation and nonspecific interaction with blood serum contents. Herein w...

NIR-dye encoded gold nanoparticles (GNP) are rapidly emerging as contrast agents in many bio-imaging/sensing applications. The coding process is usually carried out without control or a clear understanding of the metal-liquid interface properties which, in contrast, are critical in determining the type and extension of dye-metal interaction. In this paper, we investigated the effect of gold sur...

A novel and highly sensitive electrochemical method for the detection of pyritinol in pharmaceutical products and serum samples has been accomplished based on voltamperometric response of pyritinol in carbon nanofiber-gold nanoparticle (CNF-GNP)-modified screen-printed carbon electrode (SPCE). The electrochemical response of pyritinol to CNF-GNP-modified SPCE was studied by cyclic voltammetry a...

Amitrole is a biologically toxic nonselective herbicide which contaminates surface and ground waters at unprecedented rates. All reported modified electrodes that detect amitrole within sub-micromolar to nanomolar levels were based on the electro-oxidation of amitrole. Herein, we developed a new conceptual idea to detect picomolar concentrations of amitrole based on calcium cross linked pectin ...

To enhance the bioactivity of molecules through nanoparticles is being tested which has potential use in sustained-release drug delivery systems and to therapeutic effectiveness drugs. Our current investigation s conjugate lectin that a gold nanoparticle (GNP) surface without disturbing bioactive properties enhances antibacterial activity lectin. Au-lectin were checked for their hemagglutinatio...

Objective(s):   This study aimed to address the gold nanoparticle(GNP)-dose and exposure duration effect on the kidney function of rats: in vivo.   Materials and Methods: A total of 32 healthy male Wistar rats were used in this study. Animals were randomly divided into groups, three GNP-treated groups and control group. Group 1, 2 and 3 received. /5 cc of solution containing 5, 10,100 ppm Au vi...

The ligands at the surface of a gold nanoparticle (GNP) have significant influence on optical and physical properties, that may render different functionalities to GNP. Therefore, there is need in understanding nature interaction atomic resolution order allow rational design GNPs with desired physico-chemical properties. between Au $$_{79}$$ series small organic molecules has been systematicall...

Graphene Oxide (GO) is known to have two faces: it has many benefits; and hazardous our health. This study understood the jeopardizing effects of GOs in body, wanted find out a way remove body. Three sets observational studies were done evaluate detoxifying MMS2 (Calcium Hypochlorite), Hydroxychloroquine (HCQ), ivermectin, GNP (Gold Nanoparticle) + Camostat Mesylate (Foipan) on human plasma. so...