Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of intestinal epithelium towards protective effector state is important to manage inflammation immunity can be therapeutically targeted. The role epigenetic regulatory enzymes within these processes not yet defined. Here, we use mouse model that has an intestinal-epithelial speci...

In vivo conjunctival epithelial healing in albino rabbits was investigated by light microscopy following both n-heptanol and trephined conjunctival wounding. Reepithelialization occurred faster following n-heptanol treatment (3 days) versus trephination (6-7 days). No goblet cells were present in the migrating epithelium during reepithelialization. After 1 day of wounding, goblet cells disappea...

Cytochemical investigation of peroxidase was made on the conjunctival goblet cells, using the diaminobenzidine method. Many goblet cells in the conjunctiva demonstrated this reaction. The reaction was present in secretory granules as well as in the perinuclear cisterna, the rough endoplasmic reticulum, several Golgi saccules and adjacent small smooth-surfaced vesicles, and condensing vacuoles. ...

Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cel...

Goblet cell carcinoid tumor is a rare clinical entity which is usually diagnosed either as acute appendicitis or advanced cancer. Its main characteristic is that the histological findings are between those of adenocarcinoma and typical carcinoid tumor of the appendix. Goblet cell carcinoid tumors appear almost exclusively in the appendix, and prognosis depends mainly on the stage and the subtyp...

In the development of the mammalian intestine, Notch and Wnt/β-catenin signals control stem cell maintenance and their differentiation into absorptive and secretory cells. Mechanisms that regulate differentiation of progenitors into the three secretory lineages, goblet, paneth, or enteroendocrine cells, are not fully understood. Using conditional mutagenesis in mice, we observed that Shp2-media...

PURPOSE To describe goblet cell density and Nelson grading in different areas of the ocular surface using conjunctival impression cytology (CIC) among patients with normal and impaired Ocular Surface Disease Index (OSDI) scores. MATERIAL AND METHODS Patients (n=166) under assessment for dry eye were recruited between 2011 and 2012 and classified according to the OSDI score in 4 categories (no...

We examined the effect or not of an antibiotic treatment on dietary fiber-induced goblet cell proliferation in the rat ileum. The number of goblet cells in the ileum increased when rats consumed dietary fiber. However, this effect was maintained with a concurrent treatment of antibiotics, suggesting that the fiber effect on goblet cell response would remain irrespective of a bacterial component...

hedera helix  is widely used to treat bronchial asthma for many years. however, effects of this herb on lung histopathology is still far from clear. we aimed to determine the effect of oral administration of hedera helix on lung histopathology in a murine model of chronic asthma. balb/c  mice  were  divided  into  four  groups;   i  (placebo),  ii  (hedera  helix), iii (dexamethasone) and iv (c...

OBJECTIVES Aim for this study was to investigate the effect of long-acting beta2-adrenoceptor agonist formoterol on airway goblet cell hyperplasia and protein Muc5ac expression in asthmatic mice. MATERIALS AND METHODS Forty female BABL/c mice were randomly divided into four groups with 10 mice in each. Mice in group A were treated with saline as control, and mice in group B, group C and group...