Tri-isopropylsilyl thio-glycosides (TIPS S-glycosides) were synthesized through base promoted SN2 substitution of glycosyl halides with TIPS-SH or by Lewis acid promoted glycosylation of TIPS-SH with glycosyl acetates or p-methoxyphenyl glycosides. Various thioglycoside derivatives were obtained in high yields by one-pot fluoride-mediated de-silylation and thiol alkylation with alkyl halides or...

The water-soluble part of the methanolic extract from the aerial parts of Scrophularia crypthophila, through chromatographic methods, yielded three new resin glycosides, crypthophilic acids A - C (1-3). Compounds 1-3 are tetraglycosides of (+)-3S,12S-dihydroxypalmitic acid. The structures of these and 10 known compounds were elucidated by spectroscopic and chemical means. All natural resin glyc...

In the search for compounds which repress MDR1 gene expression, two novel aryl C-glycosides were isolated from a broth of Streptomyces sp. They had the characteristic structure of a dideoxy-carbohydrate (oliose or olivose) linked directly to chromomycinone, an aglycone of aureolic acids. Further investigation revealed that they were artifacts yielded from an aureolic acid, mithramycin. Acid and...

zogenes are differentiated cells capable of the biosynthesis of secondary metabolites. Hairy roots also have a high rate of proliferation. They are therefore expected to become widely used culture systems for the production of useful secondary metabolites and for studies on the production of biologically active compounds and transformation of organic substrates. We reported the production of a ...

produces the cardiac slowing, because cardiac glycosides can produce bradycardia even after bilateral severance of vagus nerves or under the effect of atropine (3, 4). Gold et al. (5, 6) suggested a direct bradycardiac action of cardiac glycosides on the heart muscle. However, the results on the effect of cardiac glycosides on the heart rate are still con troversial in the experiments with isol...