Human endometrium expresses numerous genes to achieve an optimal uterine environment for implantation and maintaining the pregnancy. In this review, we will summarize our previous observations on progestin regulated gene expression, estrogen metabolic enzymes, nitric oxide synthase, aromatase, IGF-I and II, IGFBP-1, prolactin and glycodelin. These genes are differentially activated in two types...

Glycodelin (PP14, PAEP, alpha-2-microglobulin, dimeric glycoprotein with a molecular weight of 42 to 56 kDa) is marker reproductive tissue receptivity. Immunoregulatory potential glycodelin allows us consider it among key factors that promote maternal immune tolerance the developing embryo. In general, has prospects for use in biomedicine as biopharmaceutical treat post-transplant complications...