The ingestion of dietary gluten sometimes may trigger allergic, autoimmune or nonallergic and nonautoimmune response. The typical gluten‑related allergic disorder is the wheat allergy (WA). Celiac disease (CD) is a well‑known gluten‑related autoimmune condition. The clinical expression of a gluten‑related nonallergic and nonautoimmune response is nonceliac gluten sensitivity (NCGS), an emerging...

OBJECTIVE To compare the frequency of gluten sensitivity in patients with multiple sclerosis (MS) and healthy controls. PATIENTS AND METHODS The patients were 161 clinically definite MS patients who referred to neurology outpatient clinic of Nemazee Hospital, Shiraz, south of Iran from March 2004 to October 2005. IgG and IgA antigliadin antibodies were measured by enzyme immuno assay (EIA) me...

Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing food in subjects who are not affected by either celiac disease (CD) or wheat allergy Published online: November 26, 2015 Prof. Carlo Catassi Via F Corridoni 11 IT–60123 Ancona (Italy) E-Mail c.catassi @ univpm.it © 2015 S. Karger AG, Basel 025...

We conducted online electronic searches (published manuscripts in English) of the Cochrane Library, pub med and manual searches of selected specialty journals to identify any pertinent literature. The search was conducted using the key words ‘celiac disease’, ‘gluten related disorder’, ‘non celiac gluten sensitivity’, ‘wheat allergy’, ‘gluten’, , ‘gluten free diet’. Studies not published in Eng...

OBJECTIVE To investigate the presence of autoantibody deposition against type 2 tissue transglutaminase (TG2; a reliable marker of the whole spectrum of gluten sensitivity) in the jejunal tissue and brain of patients with gluten ataxia and in control subjects. METHODS The authors evaluated jejunal biopsy samples from nine patients with gluten ataxia and seven patients with other causes of ata...

When one reads about the histologic features of celiac disease in a textbook of surgical pathology, it is the absence of normal intestinal villi that generally is stressed as the key diagnostic feature. The features of a “flat mucosa,” in combination with elongation of the intestinal crypts, evidence of epithelial damage, and a variable increase in chronic inflammation of the lamina propria, fo...

an association between coeliac disease and fertility disorders is well recognised in the current literature, but the information related to non-coeliac gluten sensitivity (ncgs) and infertility is lacking. this case highlights a possible role of treating ncgs in the reversal of infertility.