addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

The 1958 symposium of the Biochemical Society consists of seven papers given by British biochemists on areas of glutathione (GSH) chemistry and biochemistry. The topics presented may be listed briefly: chemistry of GSH, techniques for determining GSH, oxidation-reduction systems associated with GSH in plant tissues, GSH in animal tissues, and neural tissues, and in lens, and finally the effect ...

An L-glutathione-functionalized silica adsorbent was applied in this study to remove malathion from aqueous media. This has demonstrated an improved adsorption efficiency of malathion. The maximum uptake achieved 130 mg g?1 at pH 8. Equilibrium reached after about 90 min. A pseudo-second-order model best described the kinetics. isotherms were simulated by Freundlich model. functional groups are...

Mice treated with buthionine sulfoximine, an inhibitor of glutathione synthesis, showed striking alterations of morphology of lung type 2 cell lamellar bodies (swelling and disintegration) and mitochondria (degeneration) and of lung capillary endothelial cells (mitochondrial swelling). These effects probably may be ascribed to glutathione deficiency; administration of glutathione monoester prot...

the study was designed with an aim to evaluate the protective effects of reduced glutathione on cyclophosphamide induced lipid peroxidation and also changes in cholesterol content. goat liver and white new zealand rabbit were used as lipid source for the models. lipid peroxidation study was performed by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide con...