Background and Aims: Nutritional bioactive natural ingredients isolated from wild edible plants, with promising effects against diabetes and/or diabetes-related diseases continue to be investigated. There is increasing interest in these substances due their protective/therapeutic potential. The purpose of the present study investigate inhibitory potential aqueous extract Eremurus spectabilis M....

This study evaluated the in vitro antioxidative activity of Khaya senegalensis extracts and inhibitory effects of some solvent fractions on α-glucosidase and α-amylase activities. The stem bark, root and leaf samples of the plant were sequentially extracted with ethyl acetate, ethanol and water and then tested for antioxidative activity. Our findings revealed that the ethanolic extract of the r...

Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment. In the present study, a synthetic route was established as a valid approach to obtain BDDE. Fluorescence spectra, circular dichroism spectra and molecular docking methods were employed to elucidate the inhibitory mechanisms of BDDE against α-glu...

This study evaluated the in vitro antioxidative activity of Khaya senegalensis extracts and inhibitory effects of some sol vent fractions on a-glucosidase and a-amylase activities. The stem bark, root and leaf samples of the plant were sequentially extracted with ethyl acetate, ethanol and water and then tested for antioxidative activity. Our findings revealed that the ethanolic extract of the ...

BACKGROUND N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase of glycogen-debranching enzyme in the liver, in addition to possessing an antihyperglycemic action by blocking alpha-1,4-glucosidase in the intestine. Because the reduction of the glycogenolytic rate may be one of the mechanisms of myocardial p...

To examine the significance of tt-glucosidase in starch metabo]ism in vivo, wheat seedlings and seeds were treated with Bay m 1099 (Miglitol, !VLhydroxyethyl-1-deoxynojirimycin), an ct-g]ucosidase inhibitor. Bay m 1099 did not affect germination, but it inhibited growth of seed]ings at the high dosage (100pglml medium).Treatmentofnorma]lygrownseedlingswithBaym1099(1Oand1OO"glml)decreasedor-gluc...