T HE HUMAN HEMOGLOBINS consist of two pairs of peptide chains.1’2 Adult hemoglobin ( Hb-A ) has two chains designated a and two chains designated iB; it is thus represented as 2A $2A#{149}Fetal hemoglobin (Hb-F ) has two a chains, which are similar if not identical in structure to those of Hb-A, but a pair of chemically distinct chains, the y chains replacing the $ chains.3’4 Hb-F is thus repre...

Hemoglobin Abruzzo is an abnormal human hemoglobin with a substitution at a residue known to be involved in the binding of 2,3-diphosphoglyceric acid. It has increased oxygen affinity and reduced heme-heme interaction in the absence of organic or inorganic phosphate cofactors. In inorganic phosphate buffers the Bohr effect and heme-heme interaction are normal, but the oxygen affinity remains hi...

Degradation of host hemoglobin by the human malaria parasite Plasmodium falciparum is a massive metabolic process. What role this degradation plays and whether it is essential for parasite survival have not been established, nor have the roles of the various degradative enzymes been clearly defined. We report that P. falciparum can grow in medium containing a single amino acid (isoleucine, the ...

Hemoglobin M Saskatoon (ß63 His>Tyr(C-T)) is a rare hemoglobin variant that was first reported in Japan, followed by the US, Indonesia, Algeria, Russia, India, and Germany [1-8]. It was also reported in combination with another variant—Hb Hamilton [9]; however, it has yet to reported in the Turkish population [10,11]. The present report describes the first observation of this variant in an 9-ye...

We propose a phasor representation for oscillations at a given frequency (or relatively narrow frequency band) of hemoglobin concentrations in tissue, as well as hemoglobin concentrations measured by near-infrared spectroscopy. This representation provides a straightforward visualization of the phase relationships between oscillations of oxy-, deoxy-, and total hemoglobin concentrations ([HbO],...

OBJECTIVE AND METHODS Anemia is a common problem in the ICU population. Most patients are anemic at admission, their hemoglobin concentrations declining further thereafter. The aim of the present study was to evaluate the effect of a combination strategy, involving closed arterial blood gas sampling and the use of pediatric vials for phlebotomy (Group A), on the sampling-induced blood loss and ...