Background/Aim: Albuminuria is recognized as an early marker of diabetic nephropathy, but glomerular hyperfiltration appears prior to its development. The aim of this study was to assess relationship between the rates of urinary albumin excretion and glomerular filtration in different diabetic kidney disease stages of type 1 diabetes mellitus. Methods: According to urinary albumin excretion rat...

BACKGROUND Focal segmental glomerulosclerosis (FSGS) is a chronic nephropathy showing characteristic glomerular sclerosis. So far, the diagnosis and prognosis of FSGS rely mainly on the invasive biopsy. Searching for potential FSGS-associated urinary biomarkers representing pre-sclerotic and serial sclerotic stages of FSGS could be helpful to the non-invasive diagnosis and prognosis of FSGS. ...

Growth and pubertal development are important health markers. We used the data of a longitudinal growth study on a contemporary sample of US youth to examine the relationship between peak height velocity (PHV) and Tanner staging. We observed a substantial variability in the timing of PHV across Tanner stages, which is an important consideration for clinicians when assessing growth.

patients and methods blood pressure (bp) measurement was performed by the auscultation method, and abnormal glomerular permeability was assessed by dipstick testing of urine for persistent proteinuria and/or hematuria for ≥ three months in hypertensive children. results of 1,335 pupils aged 10.0 ± 2.4 (6.0 - 14.0) years, 33 (2.5%) were hypertensive. overall mean systolic/diastolic bp was 125.6 ...

Whether podocyte depletion could cause the glomerulosclerosis of aging in Fischer 344 rats at ages 2, 6, 17, and 24 mo was evaluated. Ad libitum-fed rats developed proteinuria and glomerulosclerosis by 24 mo, whereas calorie-restricted rats did not. No evidence of age-associated progressive linear loss of podocytes from glomeruli was found. Rather, ad libitum-fed rats developed glomerular enlar...

Glomerular plasminogen activator inhibitor-1 (PAI-1) steady-state mRNA and bioactivity were increased after the induction of an augmented form of antiglomerular basement membrane (GBM) antibody glomerulonephritis. PAI-1 mRNA expression was noted at 6 h, peaking at 1 day, and although falling thereafter, remained higher than that of the control group through Day 17. PAI-1 mRNA expression correla...

background: hypertension is one the most common causes of chronic kidney disease (ckd). one of the major concerns in hypertensive patients is early detection of renal disorders. in the past, serum creatinine (scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. cystatin c and neutrophil gelatinase-associated lipocal...