SUMO-interacting motifs (SIMs) play a central role in the fate of SUMO-modified proteins. Here we report a real-time SUMO-binding assay. It can be applied to the identification of SIMs and to screening for the identification of novel SUMO-binding proteins. Using this assay, we investigated the SIMs in SETDB1 and MCAF1 to gain insight into the assembly of SETDB1-MCAF1-mediated gene silencing.

lynestrenol 0.5 mg.(exlution) given to patients orally from the first day of their cycle in a continuous manner suppressed cervical mucorrhea and spinbarkeit sufficiently ennough to stop sperm penetration to the cervical canal. fern reactions were mostly negative and all post- coital examinations (sims huhner tests) showed an absence of spermatozoa.

The Higman-Sims design is an incidence structure of 176 points and 176 blocks of cardinality 50 with every two blocks meeting in 14 points. The automorphism group of this design is the Higman-Sims simple group. We demonstrate that the point set and the block set of the Higman-Sims design can be partitioned into subsets X1, X2, . . . , X11 and B1, B2, . . . , B11, respectively, so that the subst...

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) and X-ray photoelectron spectroscopy (XPS) are well established surface techniques that provide both elemental and organic information from several monolayers of a sample surface, while also allowing depth profiling or image mapping to be carried out. The static TOF-SIMS with improved performances has expanded the application of TOF-SIMS...

We meta-analytically reviewed studies that used the Structured Inventory of Malingered Symptomatology (SIMS) to detect feigned psychopathology. We present weighted mean diagnostic accuracy and predictive power indices in various populations, based on 31 studies, including 61 subsamples and 4009 SIMS protocols. In addition, we provide normative data of patients, claimants, defendants, nonclinica...