BACKGROUND Predicting the prognosis of prostate cancer disease through gene expression analysis is receiving increasing interest. In many cases, such analyses are based on formalin-fixed, paraffin embedded (FFPE) core needle biopsy material on which Gleason grading for diagnosis has been conducted. Since each patient typically has multiple biopsy samples, and since Gleason grading is an operato...

PURPOSE Prostate cancer grading with Gleason score is an important prognostic factor. This prospective randomized study compares ultrasound systematic biopsy vs contrast enhanced color Doppler targeted biopsy for the impact on Gleason score findings. MATERIALS AND METHODS We examined 690 men (mean age 56 years, range 41 to 77) with a serum total prostate specific antigen of 1.25 ng/ml or grea...

The aim of this study was to investigate the correlation of stereologically estimated volume-weighted mean nuclear volumes (MNV) with Gleason score in prostate adenocarcinomas. To estimate the MNV the point sample intercepts method was used. MNV was significantly associated with tumour differentiation, suggesting that estimates of MNV are prognostically equal or superior to morphological gradin...

preoperative gleason score (gs) obtained from trans rectal ultra sonography (trus) is the most common grading system to evaluate the appropriate treatment for patients with clinically localized prostate cancer. but this method showed upgraded and downgraded results in comparison to gleason score obtained from radical prostatectomy. the current study aimed to determine clinical or pathological v...

Donald F. Gleason in 1966 created a unique grading system for prostatic carcinoma based solely on the architectural pattern of the tumor. Another innovative aspect of this system was, rather than assigning the worst grade as the grade of the carcinoma, the grade was defined as the sum of the two most common grade patterns and reported as the Gleason score. The original description of this syste...

Prostate cancer is one of the main diseases affecting men worldwide. The gold standard for diagnosis and prognosis Gleason grading system. In this process, pathologists manually analyze prostate histology slides under microscope, in a high time-consuming subjective task. last years, computer-aided-diagnosis (CAD) systems have emerged as promising tool that could support daily clinical practice....