Objective: To investigate the correlation between postoperative pathologic grade of prostate cancer (PC) and preoperative serum PSA as well as grade of biopsy specimens. Methods: The serum PSA and preoperative and postoperative Gleason scores of PC were retrospectively analyzed in 75 patients. Correlation between serum PSA and postoperative Gleason score was evaluated, and the Gleason score bef...

BACKGROUND In the Prostate Cancer Prevention Trial, finasteride selectively suppressed low-grade prostate cancer and significantly reduced the incidence of prostate cancer in men treated with finasteride compared with placebo. However, an apparent increase in high-grade disease was also observed among men randomized to finasteride. We aimed to determine why and hypothesized that there is a grad...

Gleason grade is universally used for pathologic scoring of the differentiation of prostate cancer. However, it is unknown whether prostate tumors arise well differentiated and then progress to less differentiated forms or if Gleason grade is an early and largely unchanging feature. Prostate-specific antigen (PSA) screening has reduced the proportion of tumors diagnosed at advanced stage, which...

OBJECTIVES The aim of this study was to assess the performance of dynamic contrast-enhanced computed tomography of the prostate in patients with biopsy-proven prostate cancer. MATERIAL AND METHODS A total of 46 male patients (median age, 65 years; range, 49-73 years) with biopsy-proven prostate cancer underwent an en bloc computed tomography perfusion (CTP) scan of the prostate before surgery...

PURPOSE To evaluate the impact of primary Gleason grade in Gleason score (GS) 7 prostate cancer on biochemical recurrence (BCR) after radical prostatectomy in Korean men. MATERIALS AND METHODS We retrospectively reviewed records of 1,026 patients who underwent radical prostatectomy at Seoul National University Bundang Hospital between November 2003 and June 2009. We excluded patients who had ...

THE 2005 AND 2014 MODIFIED GLEASON GRADING SYSTEMS One of the biggest changes to the Gleason grading system was the classification of Grades 1 and 2. Grade 1 tumors are generally benign, and Grade 2 tumors do not appear to differ from those classified as Grade 3. In 2005, Grade 2 was recommended to be used “rarely, if ever,” and in the 2014 modified Gleason grading system, grading started from ...

this study was aimed at determining intra and inter-observer concordance rates in the gleason scoring of prostatic adenocarcinoma, before and after a web-based educational course. in this self-controlled study, 150 tissue samples of prostatic adenocarcinoma are re-examined to be scored according to the gleason scoring system. then all pathologists attend a free web-based course. afterwards, the...

BACKGROUND Prostate cancer is the most common malignant tumour in men and the second most common cause of male cancer death. The study examines the clinicopathological features of patients with prostate cancer consecutively diagnosed at a private Diagnostic Radiology Centre in Western Jamaica over a 6-year period. METHOD The medical records, including the pathology reports of 423 consecutive ...