mirnas are endogenous small noncoding rnas that can regulate many cellular processes. different expression levels of several mirnas have been detected in glioblastomas. function of mirnas and targets have been well studied in recent years. according to these studies, the role of mirnas in glioblastoma pathogenesis have been defined. mirnas have affected many processes in gbm such as apoptosis, ...

abstract: objective: giant cell tumor of soft parts is a rare neoplasm that mainly affects adulst and the elderly and is usually located in the extremities. here we report a child with giant cell tumor of soft tissue, which is a very rare condition in childhood. clinical presentation: a 5 year old girl presented with a 5 month history of left lower extremity pain. she had developed paraplegia b...

The B-Raf proto-oncogene serine/threonine kinase (B-Raf) is a member of the Raf kinase family. The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma, ganglioglioma, and pilocytic astrocytoma, and less frequently in epithelioid and giant cell glioblastoma. BRAF V600E mutation in these cases has been canonically detected using Sanger sequencing or...

calcifying odontogenic cyst (coc), central odontogenic fibroma (cof) and aggressive central giant cell granuloma (cgcg) are rare pathologic diseases affecting the jaws. while the co-existence of two of them is reported in the literature, existence of all three conditions in one patient is an extremely rare entity. in the present report, initial biopsy revealed fibrosarcoma, therefore mandibular...

Giant cell tumor (GCT) is a benign primary bone neoplasm that usually occurre in the long bones. The skull is affected in only 1% of cases, predominantly in the sphenoid and temporal bones. Maxillary sinus involvement is exceedingly rare. The case is a 26 year-old man presented with history of gradually increasing swelling in the right side of face without any history of trauma or systemic diso...

but were increased around areas of necrosis and around blood vessels. No relationship between tumour cell proliferation and necrosis was detected. Conclusions: Tumour cell proliferation is concentrated around blood vessels in glioblastomas. Blood vessel proliferation, but not tumour cell proliferation, is related to areas of necrosis and the presence of macrophages in glioblastomas. Targeting o...

OBJECT Recent evidence suggests that a glioma stem cell subpopulation may determine the biological behavior of tumors, including resistance to therapy. To investigate this hypothesis, the authors examined varying grades of gliomas for stem cell marker expressions and histopathological changes between primary and recurrent tumors. METHODS Tumor samples were collected during surgery from 70 pat...

The aim of this study was to examine the effect of radiation on glioblastoma, using an organotypic multicellular spheroid (OMS) model. Most glioblastoma cell lines are, in contrast to glioblastomas in vivo, relatively radiosensitive. This limits the value of using cell lines for studying the radiation effect of glioblastomas. The advantage of OMS is maintenance of the characteristics of the ori...