The objectives of this study were to compare how different frailty measures (Frailty Phenotype/FP, Groningen Frailty Indicator/GFI and Tilburg Frailty Indicator/TFI) predict short-term adverse outcomes. Secondarily, adopting a multidimensional approach to frailty (integral conceptual model-TFI), this study aims to compare how physical, psychological and social frailty predict the outcomes. A lo...

Gfi-1B is a transcriptional repressor that is crucial for erythroid differentiation: inactivation of the GFI1B gene in mice leads to embryonic death due to failure to produce differentiated red cells. Accordingly, GFI1B expression is tightly regulated during erythropoiesis, but the mechanisms involved in such regulation remain partially understood. We here identify HMGB2, a high-mobility group ...

Gastric fundus compliance allows stomach volume increase in response to food intake. Absence of this postprandial relaxation alters hormonal signals and induces early satiety and weight loss. This study demonstrates the effect of gastric fundus invagination on the growth rate of juvenile pigs. After institutional animal care and use committee approval, 15 juvenile pigs were divided into two gro...

INTRODUCTION In general, geriatric assessment (GA) provides the combined information on comorbidity and functional, nutritional and psychosocial status and may be predictive for mortality outcome of cancer patients. The impact of geriatric assessment on the outcome of older patients with colorectal cancer treated with chemotherapy is largely unknown. METHODS In a prospective study, 143 patien...

A detailed radiorespirometric and enzymological analysis was made of the wild-type and GFI strains of Thiobacillus A2 grown on numerous sugars. The wild-type used the EmbdenMeyerhof, Entner-Doudoroff and pentose phosphate pathways for glucose oxidation only after culture on glucose. The fast-growing strain GFI used all three pathways after growth on glucose, maltose or fructose. The wild-type g...

El objetivo de la investigación fue conocer relación entre el estilo motivacional del docente y satisfacción académica en los estudiantes dos universidades privadas Lima, Perú; contexto educación virtual. La cuantitativa, correlacional, no experimental e involucró 776 facultad ingeniería. Se observó una positiva significativa que fomenta autonomía (.538), mientras control obtuvo negativa con (-...

Clostridium difficile is the commonest cause of antibiotic-associated diarrhoea, with the hospitalized elderly being at particular risk. The organism makes a crystalline surface protein layer (S-layer), encoded by the slpA gene, the product of which is cleaved to give two mature peptides which associate to form the layer. The larger peptide (high molecular weight; HMW), derived from the C-termi...

The PI3K/AKT pathway plays an important role in the initiation and progression of cancer, and the drug development efforts targeting this pathway with therapeutic interventions have been advanced by academic and industrial groups. However, the clinical outcome is moderate. Combination of inhibition of PI3K/AKT and other targeted agents became a feasible approach. In this study we assessed the c...