Gestational gigantomastia is a rare condition characterized by fast, disproportionate and excessive breast growth, decreased quality of life in pregnancy, and presence of psychologic as well as physical complications. The etiology is not fully understood, although hormonal changes in pregnancy are considered responsible. Prolactin is the most important hormone. To date, 125 cases of gigantomast...

Gestational trophoblastic diseases (GTD) are a heterogenous group of disorders that arise from trophoblastic epithelium. They can follow molar pregnancy (50%), abortions (25%), normal pregnancy (22.5%), and ectopic pregnancy (2.5%) [Robert JK, Lora HE, Brigitte MR (ed) Blaustein Pathology of the Female Genital Tract 6th edn (Springer) pp. 1101-7]. Occurrence of choriocarcinoma following normal ...

Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Compute...

estational trophoblastic disease includes following forms of growth disturbance of the human trophoblast: hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumors. Term gestational trophoblastic disease is applied to the letter three conditions. Diagnosis and decision to institute treatment are sometimes undertaken without histopathological finding. Gestational tr...

BACKGROUND AND OBJECTIVES Human chorionic gonadotropin (HCG) and thyrotrophic hormone (TSH) have analogies in their structures, as well as in their receptors. The high levels of HCG seen in gestational trophoblastic diseases may induce secondary hyperthyroidism. The objective of this report was to present a case in which the administration of iodinated contrast triggered a thyrotoxic crisis. ...

Gestational trophoblastic disease is an abnormality of pregnancy that encompasses a group of diseases that differ from each other in their propensity for regression, invasion, metastasis, and recurrence. In the past, it was common for patients with molar pregnancy to present with marked symptoms: copious bleeding; theca lutein cysts; uterus larger than appropriate for gestational age; early pre...

The authors present the computed tomographic findings in a patient with malignant gestational trophoblastic neoplasia. No similar case has been described on computed tomography. The interesting aspects of the case and a brief review of this clinical entity is discussed. Pelvic computed tomography Ovary Malignant gestational trophoblastic neoplasia Theta-lutein cysts

Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms o...

M. J. Seckl1, N. J. Sebire2, R. A. Fisher1, F. Golfier3, L. Massuger4 & C. Sessa5, on behalf of the ESMO Guidelines Working Group* Department of Cancer Medicine; Department of Histopathology, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital Campus of Imperial College London, London, UK; Centre de Référence des Maladie Trophoblastiques, Hospices Civils de Lyon, Lyon...

Gestational trophoblastic disease corresponds to cystic degeneration of the trophoblast villi with excessive secretion choriogonatrophinic hormone (HCG), groups together lesions : · Benign known as hydatidiform moles (partial or complete) Malignant gestational tumors (GTT), comprising o Choriocarcinomas Invasive Trophoblastic implantation site (TTSI) Diagnosis is based on questioning and clinic...