INTRODUCTION Gestational trophoblastic disease (GTD) is a heterogeneous group of pregnancy-related disorders. Hydatidiform mole (HM) is the most common type of GTD, whereas gestational choriocarcinoma is the most aggressive. Non-receptor tyrosine kinase c-Src contributes to the transformation to a malignant phenotype in various cancers. However, the role of c-Src in the pathogenesis of GTD rema...

Gestational trophoblastic disease (GTD) is a spectrum of cellular proliferations arising from the placental villous trophoblasts encompassing four main clinicopathologic forms : hydatidiform mole (complete and partial), invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT). Placental site trophoblasic tumours (PSTT) are rare and usually diagnosed after dilatation and cure...

Gestational trophoblastic disease (GTD) is a spectrum of cellular proliferations arising from trophoblast. Their invasive and metastatic potential sometimes requires chemotherapy and/or surgery. Current management is generally associated with favourable prognosis. Therefore, treatments must be chosen according to the desire for further childbearing of each patient. The European Organisation for...

Masaharu Fukunaga, M.D. Department of Pathology, the Jikei University Daisan Hospital, Tokyo, Japan Hydatidiform moles With the increased use of ultrasound hydatidiform mole (HM) is being diagnosed at increasingly early stages of gestation. As villous edema is not fully developed, we cannot make a diagnosis of HM by macroscopic observation. Furthermore, microscopically the classic features of c...

partial or complete mole affects one in 1000  pregnancies.partial mole is a rare form of ectopic pregnancy. there was a married woman,gravid 4,parity 1,abortion 1,and she had past medical history 0f right ectopic pregnancy.she had left ectopic pregnancy and was treated by laparascopic left salpyngectomy after failure of intramascular methotrexate treatment.after surgery  the pathology exam show...

BACKGROUND: Placental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD). This tumor represents a neoplastic transformation of intermediate trophoblastic cells. We document a case of long term remission in a patient with metastatic PSTT. CASE PRESENTAION: A 27-year-old patient with metastatic PSTT was treated with combination therapy (chemothera...

BACKGROUND The aim of this study was to evaluate telomerase activity in tissue from cases of gestational trophoblastic disease (GTD) and in placental tissue from early and late human pregnancies. METHODS We used a telomeric repeat amplification protocol assay to measure telomerase activity in 132 tissue samples from normal early pregnancies, spontaneous abortions, normal late pregnancies, cas...

Placental site trophoblastic tumor (PSTT) is a very rare variant of gestational trophoblastic tumor. It can occur after normal termination of pregnancy or spontaneous abortion and ectopic or molar pregnancy. There is a wide range of clinical manifestations from a benign condition to an aggressive disease with fatal outcome. One of the most important characteristics of PSTT, unlike other forms o...

Objective We assessed the curative effect of a second curettage in patients with persistent hCG serum levels after first for gestational trophoblastic disease (GTD). Study Design This prospective observational study used data Belgian register GTD between July 2012 and January 2017. analysed who underwent curettage. included 313 database. Primary endpoints were need chemotherapy. Results Thirty-...

OBJECTIVE The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 7...