BACKGROUND Abdominal aortic aneurysm is a multifactorial disorder in which inflammation is an important pathophysiological feature. In explant culture, aneurysm biopsies secrete large amounts of interleukin-6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased. METHODS AND RESULTS We investigated, in 19 patients, whether aneurysm wall was an impo...

We report two patients with chronic liver disease--a 46-year-old man and a 52-year-old woman, both from eastern India--who were found to be infected with hepatitis C virus genotype 6 strains. These strains have been previously reported only from Hong Kong and Southeast Asia.

The objective of this study was to determine the stability 11 different rapeseed genotypes in terms seed yield, throughout 3 years (2014-2015-2016), locations (Tekirdag, Kırklareli, Edirne), total 8 environment Thrace Region. experiment designed as a randomized complete block design with four replications. aim having high adaptation for yield. Parametric (Wi2, bi, Sdi2, Bi, σi2, ri2, Sxi2, CVi ...

AIMS To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding. METHODS Mother-infant pairs provided blood for determination of 6-TGN and 6-MMPN concentrations, and TPMT genotype. RESULTS Four women taking azathioprine 1.2-2.1 mg kg(-1) day(-1) and their infants were studied. All...

Aluminum (Al) toxicity inhibits root growth, while nitrogen is an essential nutrient for plant growth and development. To explore the effects of nitrate (N) on Al accumulation in wheat, two wheat genotypes, Shengxuan 6 hao (SX6, Al-tolerant genotype) Zhenmai 168 (ZM168, Al-sensitive genotype), were used a hydroponic experiment with four treatments (control without N or Al, N, Al+N, respectively...

UNLABELLED Skeletal muscle-derived interleukin-6 (IL-6) is a pleiotropic cytokine which regulates body metabolism during strenuous physical exercise. OBJECTIVE The effect of a potentially functional single nucleotide polymorphism (SNP) -174G/C of the IL6 gene (rs1800795) promoter was examined on maximal oxygen uptake (VO2max), body mass index (BMI) and plasma IL-6 levels in response to physic...

BACKGROUND The study was undertaken to assess the influence of functional -308G/A TNF-α (rs 1800629) and -174G/C IL-6 (rs1800795) promoter polymorphisms on the therapeutic response to etanercept, a TNF-α blocker, in patients with rheumatoid arthritis (RA). METHODS Seventy-three patients suffering from active RA were studied, at baseline and 6 and 12 months after therapy. The therapeutic respo...