although more than 98% of the human genome is transcribed, most of these transcripts are not translated into proteins. rather, they are considered as non-coding rnas. micrornas (mirnas) are very short non-coding rnas approximately 22 nucleotides in length which regulate many key processes of cells such as growth, proliferation, differentiation, cell cycle, apoptosis (programmed cell death) and ...

objective: type 2 diabetes (t2d) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. however, they were largely unsuccessful while applying to the more common forms of disease. by designing genome wi...

Background: In Archaea, previous studies have revealed the presence of multiple intron-containing tRNAs and split tRNAs. The full unexpurgated analysis of archaeal tRNA genes remains a challenging task in the field of bioinformatics, because of the presence of various types of hidden tRNA genes in archaea. Here, we suggested a computational method that searched for widely separ...

In this article, we analyzed the origin of wild polyploid oats (Avena L., Poaceae) using region 18S rDNA (partially)–ITS1–5.8S obtained via NGS. There are six tetraploid (2n = 28) and four hexaploid 42) species differing by specific genome combinations: A. barbata, vaviloviana (AB), agadiriana (AB or BB), magna, murphyi, insularis (AC CD), ludoviciana, sterilis, fatua, occidentalis (ACD). We co...

in order to perform breeding programs and improve production of native chickens, preserving genetic diversity in different areas of iran is important due to the reduced available population. genome sequencing is considered the most functional approach to determine the phylogeny relation between close populations. the aim of the present study was the evaluation of the phylogeny and genetic nucle...

background recent studies suggest that rare codon clusters are functionally important for protein activity. methods here, for the first time we analyzed and reported rare codon clusters in hepatitis c virus (hcv) genome and then identified the location of these rare codon clusters in the structure of hcv protein. this analysis was performed using the sherlocc program that detects statistically ...

conclusions our findings revealed that the zfn technology could be employed to overcome ampicillin resistance by the targeted disruption of the ampicillin resistance gene, which leads to inactivation of β-lactam synthesis. therefore, zfn technology could be engaged to decrease the antibiotic resistance issue with the construction of a zfn archive against different args. to tackle the resistance...

Recently, we demonstrated chromosome instability (CIN) in human cleavage stage embryogenesis following in vitro fertilization (IVF). CIN not necessarily undermines normal human development (i.e. when remaining normal diploid blastomeres develop the embryo proper), however it can spark a spectrum of conditions, including loss of conception, genetic disease and genetic variation development. To s...