Linkage analysis is a well established method for studying the relationship between the pattern of the occurrence of a given biological trait such as a disease and the inheritance pattern of certain genes in a given family. In this paper we give some improved algorithms for the genetic linkage analysis. In particular we offer an MTBDD based version of these algorithms that turns out to be a con...

We apply the modified likelihood ratio test to two binomial mixture models arising in genetic linkage analysis. The limiting distribution of the test statistic for both models is shown to be a mixture of chi-squared distributions. A consideration of random family sizes for both models gives similar results. We also explore the power properties under local alternatives. Simulation studies show t...

linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (scz) and bipolar mood disorder (bpd) are common. numerous evidences for linkage of two diseases on chromosome 22 have been found. these findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. in the present case-control study, association ...

many agriculturally important traits are complex, affected by many genes and the environment. quantitative trait loci (qtl) mapping is a key tool for studying the genetic structure of complex traits in plants. in the present study qtls associated with yield and agronomical traits such as leaf number, leaf length, leaf width, plant height, stem and head diameter were identified by using 70 recom...

BACKGROUND Gluten sensitivity is a common multifactorial disorder, manifested in the small intestine or on the skin as typical coeliac disease or dermatitis herpetiformis, respectively. The only established genetic risk factor is HLA DQ2. AIMS We tested genetic linkage of previously reported chromosomal loci 5q and 11q in Finnish families with gluten sensitivity. We also tested if genetic lin...

Genetic  diversity  is  the  basis  of  the  natural  evolution  of  plant  breeding  and  biological  system  are  important  components  of  sustainability. The aim of this study was to evaluate 116 genotypes of Triticum turgidum from seven countries in terms of morphological traits. The results showed that high significant differences among the genotypes. The correlation between gra...

We have used the genome-wide marker genotypes from Genetic Analysis Workshop 15 Problem 2 to explore joint evidence for genetic linkage to rheumatoid arthritis across several samples. The data consisted of four high-density genome scans on samples selected for rheumatoid arthritis. We cleaned the data, removed intermarker linkage disequilibrium, and assembled the samples onto a common genetic m...