abstract  in order to study f3´5´h and f3´h function and their intraction in the grapevine flavonoids biosynthetic pathway, designing and constraction of suitable constructs encoding ihprna was performed and transgenic lines containing silencing construct of f3´h and simultaneous silencing construct of f3´5´h and f3´h were created. for this purpose, fragments were selected from both genes and i...

Gene expression regulation by small interfering RNA (siRNA) holds promise in treating a wide range of diseases through selective gene silencing. However, successful clinical application nucleic acid-based therapy requires novel delivery options. Herein, to achieve efficient negatively charged siRNA duplexes, the internal cavity “humanized” chimeric Archaeal ferritin (HumAfFt) was specifically d...