MOTIVATION Synthetic biology is to engineer artificial biological systems to investigate natural biological phenomena and for a variety of applications. However, the development of synthetic gene networks is still difficult and most newly created gene networks are non-functioning due to uncertain initial conditions and disturbances of extra-cellular environments on the host cell. At present, ho...

To understand the principles of the remarkable adaptivity of metabolic networks in dynamic environments, their underlying gene regulatory networks need to be characterised. Typically, little is known about the kinetics and topology of those gene networks in contrast to the metabolic networks that they regulate. Here, we present a theoretical approach based on metabolic control analysis to eluci...

In 2002 Eric Davidson [3] and his research team published ?A Genomic Regulatory Network for Development? in Science. The authors present the first experimental verification and systemic description of a gene regulatory network. This publication represents the culmination of greater than thirty years of work on gene regulation [4] that began in 1969 with ?A Gene Regulatory Network for Developmen...

Genome-scale metabolic models have become a fundamental tool for examining metabolic principles. However, metabolism is not solely characterized by the underlying biochemical reactions and catalyzing enzymes, but also affected by regulatory events. Since the pioneering work of Covert and co-workers as well as Shlomi and co-workers it is debated, how regulation and metabolism synergistically cha...

this paper proposes a hybrid control scheme for the synchronization of two chaotic duffing oscillator system, subject to uncertainties and external disturbances. the novelty of this scheme is that the linear quadratic regulation (lqr) control, sliding mode (sm) control and gaussian radial basis function neural network (grbfnn) control are combined to chaos synchronization with respect to extern...

Genetic regulation is often viewed as a complex system whose properties emerge from the interaction of regulatory genes. One major paradigm for studying the complex dynamics of gene regulation uses directed graphs to explore structure, behaviour and evolvability. Mutation operators used in such studies typically involve the insertion and deletion of nodes, and the insertion, deletion and rewiri...

Gene circuits that control metabolism should restore metabolic functions upon environmental changes. Whether gene networks are capable of steering metabolism to optimal states is an open question. Here we present a method to identify such optimal gene networks. We show that metabolic network optimisation over a range of environments results in an input-output relationship for the gene network t...