The bifunctional undecaprenol kinase/phosphatase (UdpK) is a small, prokaryotic, integral membrane kinase, homologous with Escherichia coli diacylglycerol kinase and expressed by the dgkA gene. In Gram-positive bacteria, UdpK involved in homeostasis of bacterial undecaprenoid pool, where it converts to undecaprenyl phosphate (C55P) also catalyses reverse process. C55P universal lipid carrier cr...

Background The development of BRAF/MEK inhibitors in patients with metastatic melanoma harboring BRAF mutations has garnered attention for liquid biopsy to detect cell-free DNA (cfDNA) using droplet digital PCR (ddPCR) or next-generation sequencing methods. Objective To investigate gene tumor and cfDNA collected from 43 evaluate their potential as biomarkers. Methods ddPCR CAncer Personalized P...

Abstract Bromodomain and extra-terminal tail (BET) proteins have been identified as potential epigenetic targets in cancer, including glioblastoma. These modifiers link the histone code to gene transcription that can be disrupted with small molecule BET inhibitors (BETi). With aim of identifying rational combination treatments for glioblastoma, we analyzed BETi-induced differential expression g...

BACKGROUND: The gene that encodes BRCA1-associated protein 1 (BAP1) has been reported to be dysregulated in several human cancers such as uveal melanoma, malignant pleural mesothelioma, hepatocellular carcinoma, thymic epithelial tumors, and clear-cell renal cell carcinoma (ccRCC). is located on the chromosome 3p21.3, encoding a deubiquitinase acts classic two-hit tumor suppressor gene. BAP1 pr...

the cross-border symposium on hepatitis c, entitled “why treating now?” was held on 15th may 2013 during the 5th international tehran hepatitis congress. the present report summarizing communicated insights during this symposium is intended to help health care providers to make well-informed decisions when treating patients with chronic hepatitis c (chc). since today’s evolving science of hepat...

schizophrenia and various neurological disorders have some signs and symptoms. visual hallucinations are one of such disorders. the related studies in some diseases for example parkinson disease and lewy body dementia indicate that acetylcholine (ach) plays a significant role in neuropsychiatric manifestation and its association with visual hallucination; therefore, visual hallucinations occur ...

in this assay, the evaluation of lipophilicity of four ace-inhibitors and hydrochlorothiazide (hctz) with rp-tlc on cellulose layers was described using three binary solvent systems. the selected ace inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with hctz. in addition, the linea...