BACKGROUND Ultrasonography of temporal arteries is not commonly used in the approach of patients with suspected giant cell arteritis (GCA) in clinical practice. A meta-analysis of primary studies available through April 2004 concluded that ultrasonography could indeed be helpful in diagnosing GCA. We specifically re-examined the diagnostic value of the ultrasonography-derived halo sign, a dark ...

If there is no pain in the temporal artery, the diagnosis of giant cell arteritis (GCA) may be delayed and blindness may occur. Therefore, FDG-PET/CT is important as a modality for diagnosis of GCA. When GCA is suspected and F-18 FDG-PET/CT is performed, it is worthwhile to pay attention to shoulder and hip joints as polymyalgia rheumatica commonly presents with GCA.

OBJECTIVES One of the most prominent features of schizophrenia is relatively lower general cognitive ability (GCA). An emerging approach to understanding the roots of variation in GCA relies on network properties of the brain. In this multi-center study, we determined global characteristics of brain networks using graph theory and related these to GCA in healthy controls and individuals with sc...

OBJECTIVE To determine the risk of newly recorded myocardial infarction (MI) and stroke among incident GCA cases compared with controls from the general population. We also evaluated time trends during follow-up. METHODS We conducted a matched cohort study (1996-2010) of all patients with incident GCA from the province of British Columbia, Canada. We estimated incidence rates of MI and stroke...

OBJECTIVE The aim of this study was to examine potential risk factors for GCA in a nested case-control study based on two prospective health surveys. METHODS We used two population-based health surveys, the Malmö Preventive Medicine Program (MPMP) and the Malmö Diet Cancer Study (MDCS). Individuals who developed GCA after inclusion were identified by linking the MPMP and MDCS databases to sev...

Objective We aimed to evaluate whether the Leganés cognitive test (LCT) correlates with global cortical atrophy (GCA) and can be used as a surrogate for structural brain damage. Methods Atahualpa residents aged > 60 years identified during a door-to-door survey underwent MRI for grading GCA. Using multivariate generalized linear models, we evaluated whether continuous LCT scores correlated wi...

OBJECTIVE To summarize the evidence about the relationship between polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). METHODS Review of relevant articles from the English-language literature. RESULTS Epidemiologic studies suggest that PMR and GCA are closely related conditions affecting people over 50 years and frequently occurring in the same patient. PMR symptoms have been obser...

The article describes clinical, including neurological manifestations, of giant cell arteritis (GCA) - granulomatous vasculitis of large and medium-sized vessels, predominantly craniofacial, including precerebral and cerebral, arteries. Histopathological features of GCA are illustrated by the schemes of panarteritis and «postarteritis» (proliferative and fibrotic changes in the intima, underlyi...

Giant cell arteritis (temporal arteritis; GCA) is a systemic vasculitis of medium and large arteries, affecting predominantly the aortic branches to the head and neck. Temporal arteritis was first described by Horton et al in 1932 and classically presents with a combination of polymyalgia rheumatica, headache, and manifestations of systemic illness (fever, anemia, anorexia, malaise, and weight ...

similar to a collection of flowers (Fig.2). They were marked by intense glucagon immunostaining. The findingswere consistentwith the recently recognized entity GCA. Mutation analysis of the tissue samples for MEN1, VHL, and p27 genes was unsuccessful because of the poor preservation of DNA within the pancreatic tissue. GCA and GCA-like entities have rarely been reported. In GCA there is no soli...