Upper gastrointestinal tract cancers are one of the most important leading causes of cancer death worldwide. Diagnosis at late stages always brings about poor outcome of these malignancies. The early detection of precancerous or early cancerous lesions of gastrointestinal tract is therefore of utmost importance to improve the overall outcome and maintain a good quality of life of patients. The ...

Although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (GI) melanoma has been reported in rare cases. In this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(NF1). Both cases showed no evidence of any lesions in skin and eye. Malignant melanoma of GI tract...

  Rectal cancer is the second most common cancer in large intestine. The prevalence and the number of young patients diagnosed with rectal cancer have made it as one of the major health problems in the world. With regard to the improved access to and use of modern screening tools, a number of new cases are diagnosed each year. Considering the location of the rectum and its adjacent organs, ma...

Occult breast cancer has frequently been described as presenting as axillary lymph node metastases but rarely as gastrointestinal metastases, Varadarajan et al. (2007). In extremely rare situations, cancerous lesions identified in the gastrointestinal tract have been determined to be metastatic lesions from primary breast cancers, Taal et al. (2000). We report a case of an occult lobular adenoc...

BACKGROUND Metastases of lobular breast cancer are commonly encountered at the level of lungs, bones, brain and liver, whereas lesions in the gastrointestinal tract are rarely seen. CASE REPORT A case of a patient with metastases in the right colon and gallbladder originating from an invasive lobular carcinoma is described. CONCLUSION Adequate diagnostic procedures should be performed in pa...

MicroRNAs (miRs) are evolutionary conserved, small non-coding RNAs with a crucial role in regulating genes expression [1]. As they target simultaneously several genes, one miR can eventually control a variety of cellular functions. Therefore, aberrations in the expression of miRs have detrimental repercussions for disease development and progression, including cancer. In the current issue, the ...

prediction of the outcome and severity of acute upper gastrointestinal bleeding (ugib) has significant importance in patient care, disposition, and determining the need for emergent endoscopy. recent international recommendations endorse using scoring systems for management of non-variceal ugib patients. to date, different scoring systems have been developed for predicting the risk of 30-day mo...