We have studied the effect of a prostaglandin E2 analogue (enprostil), on intragastric acidity, gastric acid and pepsin outputs during a 24 hour period in nine patients with duodenal ulcer in remission. Enprostil 35 micrograms bd dose inhibited 24 hour intragastric acidity by 38% and a 70 micrograms nocturnal dose by 33%. Decrease in nocturnal pepsin secretion was both volume and concentration ...

Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activity and caused no reduction in total acidity. Antipeptic activity of carbenoxo...

Adsorption of phenanthrene on carbon nanotubes (CNTs) and bioaccessibility of adsorbed phenanthrene were studied in simulated gastrointestinal fluids. Adsorption of phenanthrene on CNTs was suppressed in pepsin (800 mg/L) solution (gastric) and bile salt (500 and 5000 mg/L) fluids (intestinal). In addition to competitive sorption, pepsin and high-concentration bile salt (5000 mg/L, above critic...

EDITORIAL SYNOPSIS The pattern of gastric secretion has been studied in a series of patients following the augmented histamine test and the insulin test. In the same patient, the amount of acid and pepsin secreted is remarkably similar following these two tests. In both, acid and pepsin secretion is inhibited to a similar degree by small doses of hexamethonium and atropine. It is concluded that...

The present experiment was planned to assess the role of vagus and adrenals in gastric secretion in the pylorus ligated rats. Vagotomy significantly reduced the volume of gastric juice but the reduction following adrenalectomy was not significant. Both vagotomy and adrenalectomy significantly reduced the free acid, total acid and pepsin contents of the gastric secretion, the reduction being mor...

BACKGROUND Gastro-oesophageal reflux is common in children with cystic fibrosis (CF) and is thought to be associated with pulmonary aspiration of gastric contents. The measurement of pepsin in bronchoalveolar lavage (BAL) fluid has recently been suggested to be a reliable indicator of aspiration. The prevalence of pulmonary aspiration in a group of children with CF was assessed and its associat...

The kinetics of the gastric secretion of lipase, pepsin and acid were studied after a meal in Heidenhain-pouch rabbits. After a 24-h fast, feeding immediately stimulated (< 15 min) lipase (x 4.1) and later on pepsin (x 1.8) output which reached respectively 16 and 47% of the output observed after pentagastrin stimulation (64 micrograms.kg-1.h-1 for 1 h), and which were significantly correlated....

The gastric output of acid and pepsin in response to two doses of the cholinergic drug carbachol was measured before and two months after complete truncal vagotomy and pyloroplasty in eight patients with duodenal ulcer. After vagotomy the basal output of acid and pepsin was reduced and there was no stimulation of secretion by a subthreshold dose of carbachol (0.5 units/kg) nor was there an incr...

  Objective(s): Gastroesophageal Reflux Disease (GERD) is one of the most common digestive disorders that frequently lead to pulmonary complications due to gastric fluid aspiration. In the present experimental study, chronic aspiration of gastric fluid, its components and bile salts in rat lung was performed to find out the main factor(s) causing pulmonary complications of gastric fluid aspirat...

Fenwick (1870) was the first to discover that patients with pernicious anaemia have a deficiency of gastric pepsin, and this observation has been amply confirmed (Stockton, 1904; Levine and Ladd, 1921 ; Teschendorf, 1927; Faber, 1927; Faber and Holst, 1928 ; Johansen, 1929; Polland and Bloomfield, 1930; Castle, Heath, and Strauss, 1931 ; Davies, 1931 ; Wilkinson, 1932; Helmer, Fouts, and Zerfas...