OBJECTIVES To investigate whether all-cause mortality and deaths due to cardiovascular disease are increased in patients who have consulted primary or secondary health care with symptoms and signs of osteoarthritis (OA). METHOD This study included 383 patients with symptomatic OA at multiple sites from the Genetics ARthrosis and Progression (GARP) study (mean age 60 years, 82% women, 3693 per...

Climate warming is one of the most important threats to biodiversity. Ectothermic organisms such as amphibians and reptiles are especially vulnerable as climatic conditions affect them directly. Ecological niche models (ENMs) are increasingly popular in ecological studies, but several drawbacks exist, including the limited ability to account for the dispersal potential of the species. In this s...

The B motif is a signature of type-B response regulators (ARRs) involved in His-to-Asp phosphorelay signal transduction systems in Arabidopsis. Homologous motifs occur widely in the GARP family of plant transcription factors. To gain general insight into the structure and function of B motifs (or GARP motifs), we characterized the B motif derived from a representative ARR, ARR10, which led to a...

We consider a market model in which all commodities are inherently indivisible and thus are traded in integer quantities. We ask whether a finite set of price-quantity observations satisfying the Generalized Axiom of Revealed Preference (GARP) is consistent with utility maximization. Although familiar conditions such as non-satiation become meaningless in the current discrete model, by refining...

Cancer-associated thrombocytosis has long been linked to poor clinical outcome, but the underlying mechanism is enigmatic. We hypothesized that platelets promote malignancy and resistance to therapy by dampening host immunity. We show that genetic targeting of platelets enhances adoptive T cell therapy of cancer. An unbiased biochemical and structural biology approach established transforming g...

Dengue fever and dengue hemorrhagic fever are common mosquito-borne diseases in tropical and subtropical regions, and are mainly transmitted by the mosquito Aedes aegypti (Diptera: Culicidae). The international trade of used tires, coupled with its anthropophilic habit, has enabled Ae. aegypti to colonise new areas in China. We used Genetic Algorithum Rule-Set Production (GARP) to predict the p...

In Japan, attention is currently focused on designing ecological networks for wildlife animals. However there is an obvious lack of the species spatial information. This study aims (a) to acquire the potential spatial distribution of Asiatic black bear and Japanese serow to identify core areas, and (b) to propose a methodology for assessing needs for ecological networks. 1836 species’ point rec...

[180--90] unit at the head of the sequence provides the adjustable element to measure T 1 of 1 H attached to 13 C. The inter-sequence relaxation delay was set to 5 s and  values were 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 and 1.0 s to provide intensities for each 1 H resonance correlated to its 13 C in the modified HSQC and example intensity data are shown below for four 1 H-13 C correlations in F...

As new services requiring multicast communications become more common, the deployment of selective multicasting in bridged LANs becomes essential. The GARP/GMRP protocol, defined in the IEEE 802.1p standard, addresses this issue. The performance of this protocol depends heavily on the values of the various timers that control it. In this paper we study the performance of GARP/GMRP in terms of r...