نتایج جستجو برای: gap junction protein beta 2
تعداد نتایج: 3688275 فیلتر نتایج به سال:
Gap junctions mediate cell-cell communication in almost all tissues, but little is known about their regulation by physiological stimuli. Using a novel single-electrode technique, together with dye coupling studies, we show that in cells expressing gap junction protein connexin43, cell-cell communication is rapidly disrupted by G protein-coupled receptor agonists, notably lysophosphatidic acid,...
The expression of three different members of the gap junction multigene family, alpha 1 (Cx43), beta 1 (Cx32), and beta 2 (Cx26), was analysed in the rat implantation chamber (a structural unit containing fetal, extraembryonic and maternal components within the pregnant uterus) during mid- and late stages of gestation as well as in the delivering, post-partum and non-pregnant uterus. A differen...
BULK ISOLATION OF MOUSE HEPATOCYTE GAP JUNCTIONS Characterization of the Principal Protein, Connexin
The gap junction is a specialized contact between adjacent cells in a wide variety of tissues (1, 2) which is thought to mediate electrotonic coupling (3) . This junction is characterized by a hexagonal lattice of subunits which may be seen in lanthanum-impregnated, negative-stained, and freezefractured preparations (1) . A method for isolation of morphologically intact gap junctions from mouse...
Epidemiological evidence and studies in whole animals and cell culture have indicated that carotenoids have cancer chemopreventive action. In mouse C3H10T1/2 cells, this activity is highly correlated with the ability of carotenoids to up-regulate gap junctional intercellular communication. Here, we report that in mouse cells, carotenoids increase the expression of connexin43, a gene that encode...
Gap junction-mediated intercellular communication (GJIC) is essential for the proper function of many organs, including the lens. GJIC in lens epithelial cells is increased by FGF in a concentration-dependent process that has been linked to the intralenticular gradient of GJIC required for lens transparency. Unlike FGF, elevated levels of TGF-beta are associated with lens dysfunction. We show t...
زمینه و هدف: ناشنوایی غیر‌سندرومی مغلوب اتوزومی (ARNSHL) تا حدود 50% موارد در اثر جهش‌های ژن GJB2 (Gap junction protein, beta 2, 26kDa) کد کننده کانکسین 26 ایجاد می‌شود. با این حال 10 تا 42% از ناشنوایان دارای جهش‌های مغلوب، حامل تنها یک آلل جهش‌یافته GJB2 هستند. جهش در ژن GJB4 کد کننده‌ی کانکسین 3/30 نیز می‌تواند باعث ناشنوایی شود. هدف از این مطالعه بررسی تغییرات در ژن GJB4 به عنوان آلل دوم ...
There is a reduction in the 28-kD gap junction protein detectable by immunofluorescence in livers of partially hepatectomized rats and in cultured hepatocytes stimulated to proliferate. By the coordinate use of antibodies directed to the hepatic junction protein (HJP28) and the use of a monoclonal antibody that recognizes bromodeoxyuridine (BrdU) incorporated into DNA, we have been able to stud...
Low-density lipoprotein receptor-related protein 6 (LRP6) is a Wnt co-receptor in the canonical Wnt/β-catenin signalling. Here, we report the scaffold function of LRP6 in gap junction formation of cardiomyocytes. Cardiac LRP6 is spatially restricted to intercalated discs and binds to gap junction protein connexin 43 (Cx43). A deficiency in LRP6 disrupts Cx43 gap junction formation and thereby i...
background brucellosis is an important cosmopolitan infection disease caused by organisms belonging to the genus brucella. the cgt gene (cyclic β-1, 2 glucan transporter gene) is a virulent factor in brucella genus. the present study was conducted with the aim of cloning and expression of brucella cgt gene. materials and methods brucella melitensis cgt gene was amplified from extracted chromoso...
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