نتایج جستجو برای: galantamine
تعداد نتایج: 646 فیلتر نتایج به سال:
Generic Name: Galantamine Brand Name: Reminyl® Manufacturer: Shire Pharmaceuticals and Janssen Cilag (http://www.janssenpharmaceutica.be/index_N.asp) Summary: Galantamine hydrobromide, a phenanthrene alkaloid, is a reversible, competitive acetylcholinesterase inhibitor that is structurally unrelated to other acetylcholinesterase inhibitors (e.g, donepezil, rivastigmine, tacrine). Galantamine hy...
BACKGROUND Currently available treatments for Alzheimer's disease (AD) can produce mild improvements in cognitive function, behavior, and activities of daily living in patients, but their influence on long-term survival is not well established. This study was designed to assess patient survival and drug efficacy following a 2-year galantamine treatment in patients with mild to moderately severe...
Mild cognitive impairment (MCI) is an intermediate stage between normal cognitive status and dementia. Treatment of MCI with cholinesterase inhibitors (ChEIs) or other medications remains a controversial issue, although many experts agree that ChEIs are effective in the treatment of MCI, especially the amnestic type. We report a case of a 74-year-old Brazilian man, with memory complaints and mi...
The nerve agents soman, sarin, VX, and tabun are deadly organophosphorus (OP) compounds chemically related to OP insecticides. Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the neurotransmitter acetylcholine. The limitations of available therapies against OP poisoning are well recognized, and more effective anti...
Galantamine has emerged as a potential antidote to prevent the acute toxicity of organophosphorus (OP) compounds. Changes in inhibitory GABAergic activity in different brain regions can contribute to both induction and maintenance of seizures in subjects exposed to the OP nerve agent soman. Here, we tested the hypothesis that galantamine can prevent immediate and delayed effects of soman on hip...
BACKGROUND Metabolic syndrome (MetS) is an obesity-driven condition of pandemic proportions that increases the risk of type 2 diabetes and cardiovascular disease. Pathophysiological mechanisms are poorly understood, though inflammation has been implicated in MetS pathogenesis. The aim of this study was to assess the effects of galantamine, a centrally acting acetylcholinesterase inhibitor with ...
Background and Objective: Deleterious effect of neurotoxins on the brains of animals is an attractive research topic. In this research, the effect of microinjection of colchicine into the hippocampal CA1 was shown by examining the novelty seeking behavior. Also, the effect of pre-injection of galantamine, an effective agent in the treatment and prevention of Alzheimer's disease, for reversal of...
In Alzheimer's disease (AD), it is important to consider long-term effects, not only in patients receiving treatment, but also in subjects in whom therapy has been discontinued. The present analysis evaluates the long-term effects of galantamine on cognitive function in AD in terms of Mini-Mental State Examination (MMSE) scores for up to 7 years, using both clinical data and epidemiological mod...
BACKGROUND Sustained treatment with a cholinesterase inhibitor (ChEI) is used in the management of the symptoms of Alzheimer's disease (AD). However, the characteristic declines in learning and memory seen in AD may erode the patient's ability to adhere to medication regimens with or without caregiver support. OBJECTIVES To examine differences by type of ChEI in (1) monthly prevalence of use,...
Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System
Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer's disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was form...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید