Purpose: Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia. It known that MGUS has an increased risk progression to multiple myeloma (MM), and also prepares the ground for diseases such as Waldenstrom macroglobulinemia (WM), non-Hodgkin lymphoma, chronic lymphocytic leukemia (CLL). Our study aimed evaluate whether some important p53 pathway genes differ in ter...

Rickettsia prowazekii, a selective agent of category B, is the causative microorganism of epidemic typhus. The genome-wide profile of host response to R. prowazekii infection was studied in THP-1 cells by a human cDNA microarray. Approximately 131 (1.71%) and 11 (0.14%) genes out of 7,680 genes assessed were up-regulated or down-regulated upon infection with virulent R. prowazekii strain Breinl...

Background: Humans are exposed to ionizing radiation from different sources that include natural, occupational, medical, accidental exposures. Evaluation of the effect of low level of neutron exposure to human cells in vitro has important implications to human health. Attempts were made to measure genome damage, transcriptional profile of DNA damage response and repair genes in peripheral blood...

Ataxia-telangiectasia mutated (ATM) is a major regulator of the DNA damage response. ATM promotes the activation of BRCA1, CHK2, and p53 leading to the induction of response genes such as CDKN1A (p21), GADD45A, and RRM2B that promote cell-cycle arrest and DNA repair. The upregulation of these response genes may contribute to resistance of cancer cells to genotoxic therapies. Here, we show that ...

Chromatin regulators (CRs) are essential upstream regulatory factors of epigenetic modification. The role CRs in the pathogenesis renal ischemia-reperfusion injury (IRI) remains unclear. We analyzed a bioinformatic analysis on differentially expressed chromatin regulator genes IRI patients using data from public domains. hub identified were used to develop risk prediction model for IRI, and the...

Colo-rectal cancer (CRC) is the second-most-common cause of cancer-related death in the Western world. DNA-mismatch repair (MMR) genes regulate key cellular processes, including correction of DNA replication errors. Impaired functioning of MMR has been implicated in the aetiology of hereditary non-polyposis colon cancer and in £15% of sporadic CRC. The C4 fatty acid, butyric acid, which is prod...