1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. these compounds demonstrate low micromolar to submicromolar ic50 values against human molt 4/c8 and cem t-lymphocytes and murine leukemia l1210 cells. in this study, a comparative qsar investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...

in recent years, alternative methods have been used for estimation of soil salinity. therefore, at present research, 600 soil samples collected from ardakan in central iran. then em38 and terrain parameters such as wetness index, land index and curvature as readily measured properties and soil salinity (0-30 and 0-100) as predicted variables were measured. after that, the data set was divided i...

1-[4-(2-Alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. These compounds demonstrate low micromolar to submicromolar IC50 values against human Molt 4/C8 and CEM T-lymphocytes and murine leukemia L1210 cells. In this study, a comparative QSAR investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...

1-[4-(2-Alkylaminoethoxy) phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. These compounds demonstrate low micromolar to submicromolar IC50 values against human Molt 4/C8 and CEM T-lymphocytes and murine leukemia L1210 cells. In this study, a comparative QSAR investigation was performed on a series of 3,5-bis (arylidene)-4-piperidones using differen...

Quantitative structure-activity relationship (QSAR) study has been employed for predicting the inhibitory activities of the Hepatitis C virus (HCV) NS5B polymerase inhibitors . A data set consisted of 72 compounds was selected, and then different types of molecular descriptors were calculated. The whole data set was split into a training set (80 % of the dataset) and a test set (20 % of the dat...

A series of 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives were subjected to quantitative structure-antimicrobial activity relationships (QSAR) analysis. A collection of chemometrics methods, including factor analysis-based multiple linear regression (FA-MLR), principal component regression (PCR) and partial least squares combined with genetic algorithm for variable selection (GA-...

In this study, a new neural network quantitative structure-property relationship model for prediction of ) (LCST θ of polymer solutions is presented. The parameters of this model are eight molecular descriptors which are calculated only from the chemical structure of polymer and solvent. These eight molecular descriptors were selected from 3328 molecular descriptors of polymer and solvent avail...

Alkali-activated products composed of industrial waste materials have shown promising environmentally friendly features with appropriate strength and durability. This study explores the mechanical properties structural morphology ternary blended alkali-activated mortars materials, including fly ash (FA), palm oil (POFA), ceramic powder (WCP), granulated blast-furnace slag (GBFS). The effect on ...

AbstractPurpose We aimed to compare the diagnostic performance of PET/CT imaging performed with 68Ga-DOTA-FAPI and 18FDG in detection liver metastases patients gastrointestinal system (GIS) cancer. Methods A total 31 who underwent 18F-FDG examinations diagnosed GIS cancer (15 colorectal, 9 pancreas, 4 stomach 3 other cancers) were incl...