نتایج جستجو برای: g6pd enzyme deficiency

تعداد نتایج: 369475  

Journal: :Diabetes & metabolism 2011
C Carette D Dubois-Laforgue J-F Gautier J Timsit

AIM Epidemiological data suggest that glucose-6-phosphate dehydrogenase (G6PD) deficiency may be a risk factor for diabetes. Also, the occurrence of haemolysis in the context of diabetes crises has been reported in patients with G6PD deficiency. A unifying hypothesis could explain these associations. METHODS We report two patients in whom haemolytic crises occurred soon after acute diabetes d...

2016
Maria P. Dore Agnese Davoli Nunzio Longo Giuseppina Marras Giovanni M. Pes

Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been associated with a lower cancer risk, possibly via a reduction of mutagenic oxygen-free radicals and by reducing nicotinamide-adeninedinucleotide-phosphate for replicating cells. In Sardinia, the enzyme defect is frequent as a consequence of selection by malaria in the past. This study investigated the relationship between G6PD deficie...

Journal: :Blood 1989
E Beutler W Kuhl J L Vives-Corrons J T Prchal

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is probably the most common disease-producing genetic polymorphism of humans. Virtually all G6PD-deficient Africans show the G6PD A- phenotype, an electrophoretically rapid, deficient enzyme. The recently acquired ability to identify the point mutations producing the different variants has given us new insights into the population genetics of ...

2017
Geraldine M Clarke Kirk Rockett Katja Kivinen Christina Hubbart Anna E Jeffreys Kate Rowlands Muminatou Jallow David J Conway Kalifa A Bojang Margaret Pinder Stanley Usen Fatoumatta Sisay-Joof Giorgio Sirugo Ousmane Toure Mahamadou A Thera Salimata Konate Sibiry Sissoko Amadou Niangaly Belco Poudiougou Valentina D Mangano Edith C Bougouma Sodiomon B Sirima David Modiano Lucas N Amenga-Etego Anita Ghansah Kwadwo A Koram Michael D Wilson Anthony Enimil Jennifer Evans Olukemi K Amodu Subulade Olaniyan Tobias Apinjoh Regina Mugri Andre Ndi Carolyne M Ndila Sophie Uyoga Alexander Macharia Norbert Peshu Thomas N Williams Alphaxard Manjurano Nuno Sepúlveda Taane G Clark Eleanor Riley Chris Drakeley Hugh Reyburn Vysaul Nyirongo David Kachala Malcolm Molyneux Sarah J Dunstan Nguyen Hoan Phu Nguyen Ngoc Quyen Cao Quang Thai Tran Tinh Hien Laurens Manning Moses Laman Peter Siba Harin Karunajeewa Steve Allen Angela Allen Timothy Me Davis Pascal Michon Ivo Mueller Síle F Molloy Susana Campino Angeliki Kerasidou Victoria J Cornelius Lee Hart Shivang S Shah Gavin Band Chris Ca Spencer Tsiri Agbenyega Eric Achidi Ogobara K Doumbo Jeremy Farrar Kevin Marsh Terrie Taylor Dominic P Kwiatkowski

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against Plasmodium falciparum malaria, but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic variants with different effects in males and females, and it has heterogeneous effects on the clinical outcome of P. falciparum infection. Here we report a...

Journal: :EXCLI journal 2016
Norunaluwar Jalil Raja Zahratul Azma Emida Mohamed Azlin Ithnin Hafiza Alauddin Siti Noor Baya Ainoon Othman

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the commonest cause of neonatal jaundice in Malaysia. Recently, OSMMR2000-D G6PD Assay Kit has been introduced to quantitate the level of G6PD activity in newborns delivered in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). As duration of sample storage prior to analysis is one of the matters of concern, this study was conducted to ...

2016
Suprovath Kumar Sarker Md Tarikul Islam Grace Eckhoff Mohammad Amir Hossain Syeda Kashfi Qadri A. K. M. Muraduzzaman Golam Sarower Bhuyan Mohammod Shahidullah Mohammad Abdul Mannan Sarabon Tahura Manzoor Hussain Shahida Akhter Nazmun Nahar Tahmina Shirin Firdausi Qadri Kaiissar Mannoor

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked human enzyme defect of red blood cells (RBCs). Individuals with this gene defect appear normal until exposed to oxidative stress which induces hemolysis. Consumption of certain foods such as fava beans, legumes; infection with bacteria or virus; and use of certain drugs such as primaquine, sulfa drugs etc. may result in ly...

Journal: :Blood 1994
E Beutler

T HIRTY-FIVE YEARS ago Dr William Dameshek, the first editor of the emerging journal Blood, invited me to write a review on “The Hemolytic Effect of Primaquine.”’ At the time, primaquine sensitivity, which had just recently been shown to be caused by a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD); represented a unique example of an inherited deficiency of an enzyme that cau...

Journal: :The Southeast Asian journal of tropical medicine and public health 2003
Purnomo Suryantoro

Glucose-6-phosphate dehydrogenase (G6PD) is one of the enzymes needed by the erythrocyte to generate ATP from ADP. Deficiency of this enzyme can lead to hemolysis of red blood cells. Being a malaria endemic area, Indonesia possibly has a high incidence of G6PD deficiency. It is estimated that 2-6% of the population are carriers. In 1996, we detected 145 neonates with G6PD deficiency using the f...

Journal: :American journal of physiology. Heart and circulatory physiology 2013
Peter A Hecker Jane A Leopold Sachin A Gupte Fabio A Recchia William C Stanley

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD deficiency is the most common enzyme deficiency in humans and affects over 400 million people worldwide; however, its impact on cardiovascular disease is poorly understood. The glutathione pathway is paramount to antioxidant defense...

2013
IZ Isaac AS Mainasara Osaro Erhabor ST Omojuyigbe MK Dallatu LS Bilbis TC Adias

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human enzyme deficiencies in the world. It is particularly common in populations living in malaria-endemic areas, affecting more than 400 million people worldwide. This present study was conducted with the aim of determining the prevalence of G6PD deficiency among children visiting the Emergency Paediatric Unit of Usm...

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