Regulatory influence of the G-quadruplex or G4 motif present within the nuclease hypersensitive element (NHE) in the promoter of c-MYC has been noted. On the other hand, association of NM23-H2 to the NHE leads to c-MYC activation. Therefore, NM23-H2 interaction with the G4 motif within the c-MYC NHE presents an interesting mechanistic possibility. Herein, using luciferase reporter assay and chr...

25 G-quadruplexes (G4) are extremely stable secondary structures forming stacks of guanine 26 tetrads. DNA G4 structures have been extensively studied, however, less is known about G4 27 motifs in mRNAs, especially in their coding sequences. Herein, we show that Aven stimulates 28 the mRNA translation of the mixed lineage leukemia (MLL) proto-oncogene in an arginine 29 methylation-dependent man...

autoimmune pancreatitis is a fibro-inflammatory form of chronic pancreatitis. it is diagnosed by the combination of imaging studies such as a ct scan and pancreatography, laboratory analyses that include igg4 and/or autoantibodies, histopathological evaluations and positive response to corticosteroid therapy. we report the case of a 41-year-old female with a history of jaundice and increasing a...

polysulfide resins,with trade name of  g4 and g112, with short and long chain lengths respectively, were used as reactive modifiers to toughen epoxy resin. the effects of molecular weights of g4 and g112 on impact resistance, dielectric constant, thermal conductivity as well as decomposition  heat and adhesion properties of toughened epoxy were investigated. the impact strength and the dielectr...

Axonin-1 is an axon-associated cell adhesion molecule with dualistic expression, one form being glycophosphatidylinositol-anchored to the axonal membrane, the other secreted from axons in a soluble form. When presented as a substratum for neuronal cultures it strongly promotes neurite outgrowth from chicken embryonic dorsal root ganglia neurons. In this study, the axon-associated cell adhesion ...

G-quadruplexes (G4) are polymorphic four-stranded structures formed by certain G-rich nucleic acids, with various biological roles. However, structural features dictating their formation and/or function in vivo are unknown. In S. cerevisiae, the pathological persistency of G4 within the CEB1 minisatellite induces its rearrangement during leading-strand replication. We now show that several othe...

G-quadruplex or G4 DNA is a non-B secondary DNA structure that comprises a stacked array of guanine-quartets. Cellular processes such as transcription and replication can be hindered by unresolved DNA secondary structures potentially endangering genome maintenance. As G4-forming sequences are highly frequent throughout eukaryotic genomes, it is important to define what factors contribute to a G...

Definition 4. We label lines 4-8 of the 4PPC algorithm as the reinstate procedure. This procedure reinstates a timepoint vk by, for every pair of previously-reinstated, neighboring timepoints vi and vj, tightening edge eki and edge ejk with respect to eij. Lemma 1. Let o and o′ be two distinct total orderings of the vertices, V for some graph G = 〈V,E〉. If o′ is consistent with the precedence r...

G-quadruplexes (G4) are tetrahelical structures formed from planar arrangement of guanines in nucleic acids. A simple, regular motif was originally proposed to describe G4-forming sequences. More recently, however, formation of G4 was discovered to depend, at least in part, on the contextual backdrop of neighboring sequences. Prediction of G4 folding is thus becoming more challenging as G4 outl...

G-quadruplexes (G4s) are noncanonical DNA/RNA structures formed by guanine-rich sequences. Recently, G4s have been found not only in aptamers but also in the genomic DNA and transcribed RNA. In this study, we identified new RNA oligonucleotides working as aptamers by focusing on G4-forming RNAs located within the pre-mRNA. We showed that the G4 in the 5' UTR and first intron of VEGFA bound to t...