In many domains, the combined opinion of a committee of experts provides better decisions than the judgment of a single expert. This paper shows how to implement a successful ensemble strategy for predicting recovery rates on defaulted debts. Using data from Moody’s Ultimate Recovery Database, it is shown that committees of models derived from the same regression method present better forecasts...

We uncover significant effects of jump risk on conditional equity premium. Realized volatility due to negative or “bad” (positive or “good”) jumps in stock market prices predicts a rising (falling) near-term equity premium. The forecasting power of signed jump risk measures remains statistically significant even when we control for variance risk premium that Drechsler and Yaron (2011) attribute...

Portfolio optimization inputs differ widely from their subsequent out-of-sample (OOS) values. As a result, optimized portfolios have 2 to 28 times more risk OOS than their ex-ante estimates suggest. I propose a simple solution to this problem: let the data speak for itself and pick, in real time, the correction that most reduces past OOS errors. The resulting optimized portfolios consistently o...

Background: Gastric cancer is one of the most common types worldwide. Helicobacter pylori infection clearly correlated with gastric carcinogenesis. Therefore, use a new non-invasive test, known as GastroPanel can be very helpful to identify patients at high risk, including those atrophic gastritis, intestinal metaplasia, and dysplasia. This study aimed compare results test pathological findings...

To explore the mechanisms of the effects of sucralfate on the stomach, we investigated the action of sucrose octasulfate (SOS), a constituent of sucralfate, on the function of canine gastric parietal cells and somatostatin cells and in the isolated perfused intact rat stomach. Somatostatin cells from the canine gastric fundus were isolated by EDTA-collagenase dispersion and counterflow elutriat...

BACKGROUND AND AIMS Elevated circulating concentrations of the hormone gastrin contribute to the development of gastric adenocarcinoma and types-1 and 2 gastric neuroendocrine tumors (NETs). MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate proteins which in turn influence various biological processes. We hypothesised that gastrin induces the expression of specif...

The molecular species of gastrin in the circulation and in tumor extracts were studied in two groups of patients: (1) with benign gastrinoma and (2) with gastrinoma with liver metastases. Radioimmunoassays (RIAs) and immunoaffinity chromatography for the amino (NH2)- and amidated COOH-terminus of gastrin-17 (antiserum G17) and the NH2-terminus of gastrin-34 (antiserum G34) were employed. In bot...