This study was conducted to investigate the effects of dietary fructooligosaccharides (FOS) on growth, survival rate, digestive enzyms activity, and expression intestinal barrier function genes in tropical gar (Atractosteus tropicus) larvae. A total 960 larvae (0.030 ± 0.006 g) were fed three diets supplemented with increasing FOS concentrations (2.5, 5, 7.5 g kg?1) a control diet for 15 days. ...

The pathological role of interferon-g (IFN-g) in atherosclerosis is mediated through effects on macrophages, foam cells, and other vascular cells. Recently, we reported that ABC1 message and protein levels were decreased 3to 4-fold in foam cells by IFN-g. In the present study, the pathway by which IFN-g inhibited ABC1 expression was investigated with Stat1 knockout mice. IFN-g–stimulated, wild-...

Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...

Women usually experience body weight gain with aging, which can put them at risk for many chronic diseases. Previous studies indicated that melatonin treatment attenuates and abdominal fat deposition in several male animals. However, it is unclear whether affects female animals the same way. This study investigated long-term attenuate aging and, if does, what mechanism is. Ten-week-old ICR mice...

In this review we describe the potential role(s) of superoxide in inflammatory disorders.

Acupuncture or electroacupuncture (EA) has been demonstrated to have a powerful antihypernociceptive effect on inflammatory pain. The attenuation of G protein-coupled receptor kinase 2 (GRK2) in spinal cord and peripheral nociceptor has been widely acknowledged to promote the transition from acute to chronic pain and to facilitate the nociceptive progress. This study was designed to investigate...

UNLABELLED Pertuzumab is a HER2 dimerization inhibitor that binds to an epitope unique from that of trastuzumab. Our objective was to determine whether SPECT with (111)In-diethylenetriaminepentaacetic acid-pertuzumab ((111)In-DTPA-pertuzumab) could sensitively detect an early molecular response to trastuzumab manifested by HER2 downregulation and a later tumor response revealed by a decreased n...

Background The G protein-coupled receptor 55 (GPR55) has recently been suggested to be responsible for those cannabinoid responses that could not be attributed to either the cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor. Several potent GPR55 agonists were identified such as lysophosphatidylinositol (LPI) and several synthetic cannabinoids: One of these is rimonabant (SR141716A), an antago...