نتایج جستجو برای: fxr

تعداد نتایج: 1033  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2012
Natarajan Balasubramaniyan Meena Ananthanarayanan Frederick J Suchy

The farnesoid X receptor (FXR) is a ligand (bile acid)-dependent nuclear receptor that regulates target genes involved in every aspect of bile acid homeostasis. Upon binding of ligand, FXR recruits an array of coactivators and associated proteins, some of which have intrinsic enzymatic activity that modify histones or even components of the transcriptional complex. In this study, we show chroma...

2015
Jurema Schmidt Franca-Maria Klingler Ewgenji Proschak Dieter Steinhilber Manfred Schubert-Zsilavecz Daniel Merk

The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as cellular sensor for bile acids. In this role, FXR is a highly important liver protector and FXR inhibition by antagonists or knockout has shown several deleterious effects. A recent report characterized non-steroidal anti-rheumatic drugs (NSAIDs) such as ibuprofen or diclofenac as FXR antagonists and l...

Journal: :The Journal of biological chemistry 2003
Parinaz C Pircher Jennifer L Kitto Mary L Petrowski Rajendra K Tangirala Eric D Bischoff Ira G Schulman Stefan K Westin

The farnesoid X receptor (FXR; NR1H4) regulates bile acid and lipid homeostasis by acting as an intracellular bile acid-sensing transcription factor. Several identified FXR target genes serve critical roles in the synthesis and transport of bile acids as well as in lipid metabolism. Here we used Affymetrix micro-array and Northern analysis to demonstrate that two enzymes involved in conjugation...

Journal: :Circulation research 2006
Fengtian He Jiang Li Ying Mu Ramalinga Kuruba Zheng Ma Annette Wilson Sean Alber Yu Jiang Troy Stevens Simon Watkins Bruce Pitt Wen Xie Song Li

The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is highly expressed in liver, kidney, adrenals, and intestine. FXR may play an important role in the pathogenesis of cardiovascular diseases via regulating the metabolism and transport of cholesterol. In this study, we report that FXR is also expressed in rat pulmonary artery endothelial cells (EC), a "nonclassi...

Journal: :The Journal of clinical investigation 2006
Ke Ma Pradip K Saha Lawrence Chan David D Moore

The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory role in glucose homeostasis. FXR-null mice developed severe fatty liver and elevated circulating FFAs, which was associated with elevated serum glucose and impaired glucose and insulin tolerance. Their insulin resistance was confirmed by...

Journal: :Journal of lipid research 2006
Hans Lee Yanqiao Zhang Florence Y Lee Stanley F Nelson Frank J Gonzalez Peter A Edwards

Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the role of FXR in the latter two organs is unknown. In the current study, we performed microarray analysis using RNA from H295R cells infected with constitutively active FXR. Several putative FXR target genes were identified, including the organic solute transporters alph...

Journal: :Hepatology 2018
Michael D Thompson Akshata Moghe Pamela Cornuet Rebecca Marino Jianmin Tian Pengcheng Wang Xiaochao Ma Marc Abrams Joseph Locker Satdarshan P Monga Kari Nejak-Bowen

Cholestatic liver diseases result from impaired bile flow and are characterized by inflammation, atypical ductular proliferation, and fibrosis. The Wnt/β-catenin pathway plays a role in bile duct development, yet its role in cholestatic injury remains indeterminate. Liver-specific β-catenin knockout mice and wild-type littermates were subjected to cholestatic injury through bile duct ligation o...

2015
Fei Guo Zhizhen Xu Yan Zhang Peng Jiang Gang Huang Shan Chen Xilin Lyu Ping Zheng Xin Zhao Yijun Zeng Shuguang Wang Fengtian He

Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 (STAT3) activity. Farnesoid X Receptor (FXR), highly expressed in liver, has an important role in protecting against hepatocellular carcinoma (HCC). However, it is unclear whether the tumor suppressive activity of FXR inv...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Nadine Honke Namir Shaabani Cornelia Hardt Caroline Krings Dieter Häussinger Philipp A Lang Karl S Lang Verena Keitel

BACKGROUND Bile acids (BAs) are steroid molecules that are synthesized in the liver. In addition to their important role as a surfactant in solubilizing lipids and promoting the absorption of lipids in the gastrointestinal tract, they act as inflammagens. The role of BAs and their receptor farnesoid X receptor (FXR) during viral infection has not been studied in detail. METHODS By using FXR-d...

Journal: :The Journal of biological chemistry 2003
Annie Zhao Jane-L Lew Li Huang Jinghua Yu Theresa Zhang Yaroslav Hrywna John R Thompson Nuria de Pedro Richard A Blevins Fernando Peláez Samuel D Wright Jisong Cui

Human kininogen belongs to the plasma kallikreinkinin system. High molecular weight kininogen is the precursor for two-chain kinin-free kininogen and bradykinin. It has been shown that the two-chain kinin-free kininogen has the properties of anti-adhesion, anti-platelet aggregation, and anti-thrombosis, whereas bradykinin is a potent vasodilator and mediator of inflammation. In this study we sh...

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